SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 VAL A 441
VAL A 443
TRP A 407
 None
 0.87A 1bdwA-4jkmA:
undetectable
1bdwB-4jkmA:
undetectable		 1bdwA-4jkmA:
4.10
1bdwB-4jkmA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 7 ARG A 329
TYR A 472
ARG A 563
ASN A 567
 None
 1.20A 1f9gA-4jkmA:
undetectable		 1f9gA-4jkmA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 11 LEU A 361
GLY A 358
TYR A 423
ILE A 381
HIS A 387
 None
 1.36A 1tmxA-4jkmA:
undetectable		 1tmxA-4jkmA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 12 GLY A 296
TYR A 335
ILE A 351
ARG A 329
HIS A 332
 None
 1.31A 1tmxB-4jkmA:
2.8		 1tmxB-4jkmA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 361
GLY A 358
TYR A 423
ILE A 381
HIS A 387
 None
 1.32A 1tmxB-4jkmA:
2.8		 1tmxB-4jkmA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 6 THR A  91
PHE A 110
PHE A 163
ASN A 167
 None
 1.26A 1tt0C-4jkmA:
1.1		 1tt0C-4jkmA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 11 GLN A 559
PHE A 165
ASP A 300
ARG A 574
ASP A  61
 None
 1.37A 2a68C-4jkmA:
0.0
2a68F-4jkmA:
0.0		 2a68C-4jkmA:
20.35
2a68F-4jkmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 SER A 415
ASP A 458
CYH A 496
 None
 1.15A 2br4E-4jkmA:
undetectable		 2br4E-4jkmA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 5 ALA A 325
ALA A 343
GLN A 548
VAL A 405
 None
 0.94A 2nyrB-4jkmA:
undetectable		 2nyrB-4jkmA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 6 HIS A 401
ARG A 341
ASN A 400
GLU A 269
 None
 1.44A 3galA-4jkmA:
undetectable		 3galA-4jkmA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 12 ASN A 411
VAL A 444
GLY A 296
ASN A 551
ARG A 576
 None
 0.92A 3k13B-4jkmA:
10.1		 3k13B-4jkmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 THR A 330
ASP A 398
GLU A 337
 None
 0.84A 3qowA-4jkmA:
undetectable		 3qowA-4jkmA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 ASN A 133
TRP A  65
ASP A 137
 None
 1.31A 4a7tA-4jkmA:
3.8
4a7tF-4jkmA:
3.2		 4a7tA-4jkmA:
14.38
4a7tF-4jkmA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 LEU A 242
ARG A 274
MET A 406
 None
 0.97A 4m11C-4jkmA:
undetectable		 4m11C-4jkmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 7 PRO A 112
SER A 336
GLU A 338
ASP A 316
 None
 1.24A 4uacA-4jkmA:
undetectable		 4uacA-4jkmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 ALA A 131
TRP A  65
VAL A  66
 None
 0.38A 4w9nC-4jkmA:
undetectable		 4w9nC-4jkmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 7 LEU A 103
GLU A  31
ILE A 171
VAL A 130
 None
 0.80A 5jh7C-4jkmA:
undetectable		 5jh7C-4jkmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 THR A 111
PRO A 334
ASP A 352
 None
 0.93A 5l8dB-4jkmA:
undetectable		 5l8dB-4jkmA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUR_B_STRB201_1
(AVIDIN)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 11 VAL A 443
TRP A 378
PHE A 424
THR A 377
ASN A 162
 None
 1.42A 5lurB-4jkmA:
0.8		 5lurB-4jkmA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 THR A 111
PRO A 334
ASP A 352
 None
 0.93A 5mwuB-4jkmA:
undetectable		 5mwuB-4jkmA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 391
PHE A 424
PRO A 413
GLY A 358
LEU A 359
 None
 1.08A 5ogcB-4jkmA:
undetectable		 5ogcB-4jkmA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 7 ALA A 410
THR A 354
ILE A 390
LEU A 391
 None
 0.81A 5te8A-4jkmA:
undetectable		 5te8A-4jkmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 8 ALA A 410
THR A 354
ILE A 390
LEU A 391
 None
 0.74A 5te8B-4jkmA:
undetectable		 5te8B-4jkmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		4 / 7 THR A 383
LEU A 430
LYS A 432
VAL A 441
 None
 1.10A 5tudA-4jkmA:
undetectable		 5tudA-4jkmA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 SER A 417
HIS A 360
TYR A 446
 None
 0.99A 5y2tA-4jkmA:
undetectable		 5y2tA-4jkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 ARG A 329
ILE A 351
SER A 408
 None
 0.85A 5zw2A-4jkmA:
undetectable		 5zw2A-4jkmA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 4jkm BETA-GLUCURONIDASE
(Clostridium
perfringens) 		3 / 3 TRP A 407
ILE A 351
ASP A 352
 None
 0.59A 6i0y7-4jkmA:
undetectable		 6i0y7-4jkmA:
3.81