SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOF_C_FRDC305_2 (POL POLYPROTEIN PEPTIDE INHIBITOR)	4jkw	BUTYROPHILIN SUBFAMILY 3 MEMBER A1 (Homo sapiens)	4 / 5	LEU A 73 ASP A 75 PRO A 24 ALA A 83	None	0.94A	2aofB-4jkwA: undetectable	2aofB-4jkwA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOH_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	4jkw	BUTYROPHILIN SUBFAMILY 3 MEMBER A1 (Homo sapiens)	4 / 5	LEU A 73 ASP A 75 PRO A 24 ALA A 83	None	0.92A	2aohA-4jkwA: undetectable	2aohA-4jkwA: 20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJT_A_SAMA501_1 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	4jkw	BUTYROPHILIN SUBFAMILY 3 MEMBER A1 (Homo sapiens)	3 / 3	ARG A 74 ASP A 103 ASP A 105	None	0.67A	2ejtA-4jkwA: undetectable	2ejtA-4jkwA: 16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EYS_A_ACTA402_0 (MCCC FAMILY PROTEIN)	4jkw	BUTYROPHILIN SUBFAMILY 3 MEMBER A1 (Homo sapiens)	4 / 6	SER A 94 ASP A 93 SER A 92 GLU A 118	None	1.07A	4eysA-4jkwA: undetectable	4eysA-4jkwA: 17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QTU_B_SAMB301_1 (PUTATIVE METHYLTRANSFERASE BUD23)	4jkw	BUTYROPHILIN SUBFAMILY 3 MEMBER A1 (Homo sapiens)	4 / 5	GLN A 47 SER A 42 ASP A 93 ASP A 20	None	1.36A	4qtuB-4jkwA: undetectable	4qtuB-4jkwA: 22.60

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AOF_C_FRDC305_2","POL POLYPROTEIN;PEPTIDE INHIBITOR","4jkw","BUTYROPHILIN SUBFAMILY 3 MEMBER A1","Homo sapiens",4,"LEU A  73;ASP A  75;PRO A  24;ALA A  83","None","0.94A","2aofB-4jkwA:undetectable","2aofB-4jkwA:20.49"],["2AOH_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","4jkw","BUTYROPHILIN SUBFAMILY 3 MEMBER A1","Homo sapiens",4,"LEU A  73;ASP A  75;PRO A  24;ALA A  83","None","0.92A","2aohA-4jkwA:undetectable","2aohA-4jkwA:20.49"],["2EJT_A_SAMA501_1","N(2),N(2)-DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE","4jkw","BUTYROPHILIN SUBFAMILY 3 MEMBER A1","Homo sapiens",3,"ARG A  74;ASP A 103;ASP A 105","None","0.67A","2ejtA-4jkwA:undetectable","2ejtA-4jkwA:16.25"],["4EYS_A_ACTA402_0","MCCC FAMILY PROTEIN","4jkw","BUTYROPHILIN SUBFAMILY 3 MEMBER A1","Homo sapiens",4,"SER A  94;ASP A  93;SER A  92;GLU A 118","None","1.07A","4eysA-4jkwA:undetectable","4eysA-4jkwA:17.56"],["4QTU_B_SAMB301_1","PUTATIVE METHYLTRANSFERASE BUD23","4jkw","BUTYROPHILIN SUBFAMILY 3 MEMBER A1","Homo sapiens",4,"GLN A  47;SER A  42;ASP A  93;ASP A  20","None","1.36A","4qtuB-4jkwA:undetectable","4qtuB-4jkwA:22.60"]]