SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jkz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LYS A  42
LEU A  25
ALA A  38
LEU A  34
 None
 1.24A 1f86B-4jkzA:
undetectable		 1f86B-4jkzA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ARG A 181
THR A  83
VAL A  82
ALA A  90
 None
 0.91A 1fo4B-4jkzA:
undetectable		 1fo4B-4jkzA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 181
THR A  83
VAL A  82
ALA A 180
 None
 1.07A 2e1qA-4jkzA:
undetectable		 2e1qA-4jkzA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A  60
TYR A  51
ILE A  36
ALA A  40
 None
 0.95A 3n8yB-4jkzA:
undetectable		 3n8yB-4jkzA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A  99
THR A 108
LEU A  26
 None
 0.62A 5m66D-4jkzA:
undetectable		 5m66D-4jkzA:
17.92