SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jlc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 7 THR A 542
ASN A 548
THR A 431
TYR A 394
 None
 0.92A 1bu5A-4jlcA:
undetectable		 1bu5A-4jlcA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ4_A_CAMA502_0
(CYTOCHROME P450-CAM)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.17A 1dz4A-4jlcA:
undetectable		 1dz4A-4jlcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		5 / 12 ILE A 345
VAL A 381
LEU A 352
ILE A 324
ILE A 326
 None
 0.93A 1epbB-4jlcA:
undetectable		 1epbB-4jlcA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		8 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
VAL A  68
ASN A 140
THR A 156
ASP A 157
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.5A)
None
 0.87A 1fmoE-4jlcA:
17.6		 1fmoE-4jlcA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		5 / 11 GLU A 111
LEU A 107
PRO A 108
HIS A 213
ALA A 214
 None
 1.34A 1mjqI-4jlcA:
undetectable
1mjqJ-4jlcA:
undetectable		 1mjqI-4jlcA:
9.75
1mjqJ-4jlcA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 5 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.18A 1t88B-4jlcA:
undetectable		 1t88B-4jlcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
LYS A 137
ASN A 140
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.4A)
None
None
 1.00A 2fumB-4jlcA:
20.8		 2fumB-4jlcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
ASN A 140
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.4A)
None
 0.78A 2fumC-4jlcA:
20.9		 2fumC-4jlcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
GLY A  16
GLY A  18
VAL A  23
ALA A  36
MET A  86
LYS A 137
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.4A)
None
 0.86A 2fumD-4jlcA:
20.8		 2fumD-4jlcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
GLY A  16
VAL A  23
ALA A  36
MET A  86
LYS A 137
ASN A 140
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.4A)
None
None
 0.78A 2fumD-4jlcA:
20.8		 2fumD-4jlcA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 5 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.21A 2m56A-4jlcA:
undetectable		 2m56A-4jlcA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 4 ALA A 367
VAL A 310
PHE A 335
THR A 373
 None
 1.27A 2pkkA-4jlcA:
undetectable		 2pkkA-4jlcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
GLY A  16
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.5A)
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
 0.67A 3c7qA-4jlcA:
18.1		 3c7qA-4jlcA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		5 / 10 LEU A  15
VAL A  23
LYS A  38
VAL A  68
PHE A  88
 SU6  A 701 (-3.6A)
None
None
None
SU6  A 701 (-4.0A)
 0.60A 3cs9A-4jlcA:
18.4		 3cs9A-4jlcA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 5 ARG A 525
ILE A 522
TYR A 454
THR A 457
 None
 1.46A 3dgqA-4jlcA:
undetectable		 3dgqA-4jlcA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.10A 3fwgA-4jlcA:
undetectable		 3fwgA-4jlcA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 11 LEU A  15
VAL A  23
ALA A  36
VAL A  68
CYH A  89
GLY A  92
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
 0.54A 3g0eA-4jlcA:
17.8		 3g0eA-4jlcA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 8 LEU A 277
PRO A 220
SER A 247
GLY A 217
 None
 1.14A 3hcrA-4jlcA:
undetectable		 3hcrA-4jlcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
PHE A 158
GLY A 159
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
 0.71A 3og7A-4jlcA:
20.9		 3og7A-4jlcA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.11A 3wrhE-4jlcA:
undetectable		 3wrhE-4jlcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.14A 3wrjE-4jlcA:
undetectable		 3wrjE-4jlcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
CYH A  89
GLY A  92
PHE A 158
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.60A 3wzdA-4jlcA:
18.3		 3wzdA-4jlcA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
None
None
 0.50A 3wzeA-4jlcA:
18.2		 3wzeA-4jlcA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 11 LEU A  15
ALA A  36
VAL A  68
PHE A  88
CYH A  89
GLY A  92
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
 0.42A 4agdA-4jlcA:
17.9		 4agdA-4jlcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
LEU A 126
HIS A 133
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
None
None
 0.68A 4asdA-4jlcA:
18.1		 4asdA-4jlcA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.11A 4ek1A-4jlcA:
undetectable		 4ek1A-4jlcA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.15A 4g3rA-4jlcA:
undetectable		 4g3rA-4jlcA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 7 TRP A 205
ILE A 246
THR A 278
ASP A 288
 None
 1.40A 4iarA-4jlcA:
2.5		 4iarA-4jlcA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		3 / 3 GLY A 139
GLU A  99
THR A  96
 None
None
SU6  A 701 (-2.9A)
 0.56A 4kouA-4jlcA:
undetectable		 4kouA-4jlcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 5 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.13A 4l49A-4jlcA:
undetectable		 4l49A-4jlcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 PHE A 112
LEU A 281
VAL A 280
VAL A 119
 None
 1.13A 4l4cA-4jlcA:
undetectable		 4l4cA-4jlcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 ASP A 569
ALA A 412
TYR A 563
ASP A 586
 None
 1.18A 4mdaA-4jlcA:
undetectable		 4mdaA-4jlcA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 ASP A 569
ALA A 412
TYR A 563
ASP A 586
 None
 1.16A 4mdbA-4jlcA:
undetectable		 4mdbA-4jlcA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 ARG A 574
ASP A 407
VAL A 418
ALA A 417
 None
 0.79A 4nkxA-4jlcA:
undetectable		 4nkxA-4jlcA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		5 / 12 ALA A  36
LYS A  38
SER A  93
PHE A 158
GLY A 159
 SU6  A 701 (-3.4A)
None
None
None
None
 0.85A 4rzvA-4jlcA:
21.4		 4rzvA-4jlcA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
SER A  93
PHE A 158
GLY A 159
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
None
 0.88A 4rzvB-4jlcA:
20.8		 4rzvB-4jlcA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		8 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
PHE A  88
GLY A  92
ASN A 140
ASP A 157
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
None
None
 0.82A 4twpB-4jlcA:
18.6		 4twpB-4jlcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 LEU A  15
VAL A  23
LYS A  38
ILE A  67
 SU6  A 701 (-3.6A)
None
None
None
 0.45A 4tyjA-4jlcA:
18.4		 4tyjA-4jlcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
ASP A 157
PHE A 158
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
 0.97A 4xv2A-4jlcA:
20.3		 4xv2A-4jlcA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 LEU A  15
ALA A  36
PHE A  88
CYH A  89
GLY A  92
ASP A 157
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.73A 5ajqA-4jlcA:
19.1		 5ajqA-4jlcA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		5 / 12 VAL A  23
ALA A  36
LYS A  38
CYH A  89
PHE A 158
 None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
 0.85A 5cswA-4jlcA:
20.1		 5cswA-4jlcA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 6 ARG A 574
GLY A 410
ASP A 409
ASP A 411
 None
 1.22A 5hp1A-4jlcA:
4.5		 5hp1A-4jlcA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 8 ILE A 114
ARG A 143
LEU A  98
ASN A 103
 None
 1.04A 5hwaA-4jlcA:
undetectable		 5hwaA-4jlcA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		5 / 10 LEU A  15
VAL A  23
LYS A  38
PHE A  88
GLY A  92
 SU6  A 701 (-3.6A)
None
None
SU6  A 701 (-4.0A)
SU6  A 701 (-3.8A)
 0.62A 5mo4A-4jlcA:
13.3		 5mo4A-4jlcA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 10 LEU A  15
VAL A  23
ALA A  36
VAL A  68
MET A  86
THR A 156
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.5A)
 0.72A 5n3hA-4jlcA:
17.4		 5n3hA-4jlcA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		4 / 5 LEU A  15
VAL A  23
MET A  86
CYH A  89
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.8A)
 0.48A 5te0A-4jlcA:
18.8		 5te0A-4jlcA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 LEU A  15
ALA A  36
LYS A  38
VAL A  68
LEU A  84
GLY A  92
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
None
None
SU6  A 701 (-3.8A)
 0.90A 5vcvA-4jlcA:
18.3		 5vcvA-4jlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
CYH A  89
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.8A)
 0.57A 5vcyA-4jlcA:
17.5		 5vcyA-4jlcA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		6 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  84
GLY A  92
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.8A)
 0.92A 5vcyA-4jlcA:
17.5		 5vcyA-4jlcA:
19.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		8 / 9 ALA A  36
VAL A  68
MET A  86
CYH A  89
GLY A  92
THR A  96
MET A 142
THR A 156
 SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.4A)
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
SU6  A 701 (-2.9A)
SU6  A 701 (-4.2A)
SU6  A 701 (-3.5A)
 0.63A 5w5vA-4jlcA:
37.5		 5w5vA-4jlcA:
93.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		8 / 9 LEU A  15
ALA A  36
VAL A  68
CYH A  89
GLY A  92
THR A  96
MET A 142
THR A 156
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
SU6  A 701 (-2.9A)
SU6  A 701 (-4.2A)
SU6  A 701 (-3.5A)
 0.53A 5w5vA-4jlcA:
37.5		 5w5vA-4jlcA:
93.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_B_IREB401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
ALA A  36
LYS A  38
LEU A  84
CYH A  89
GLY A  92
ASP A 157
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.61A 5y7zB-4jlcA:
18.1		 5y7zB-4jlcA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Mus
musculus) 		7 / 12 LEU A  15
VAL A  23
ALA A  36
LYS A  38
CYH A  89
GLY A  92
ASP A 157
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.54A 5y80A-4jlcA:
6.0		 5y80A-4jlcA:
7.91