SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jlr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 4jlr MOTAVIZUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 ARG H  66
PRO H  41
LEU H  20
LEU H  18
ASP H  86
 None
 1.32A 1e7wA-4jlrH:
undetectable		 1e7wA-4jlrH:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 4jlr MOTAVIZUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 TYR H  59
LEU H  20
LEU H  18
MET H  82
TYR H  90
 None
 1.13A 1p33C-4jlrH:
undetectable		 1p33C-4jlrH:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 4jlr MOTAVIZUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 9 LEU H  18
ILE H  51
GLY H  35
ILE H  37
VAL H  82
 None
 1.14A 2r5qA-4jlrH:
undetectable		 2r5qA-4jlrH:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 4jlr MOTAVIZUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 9 LEU H  18
ILE H  51
GLY H  35
ILE H  37
VAL H  82
 None
 1.14A 2r5qC-4jlrH:
undetectable		 2r5qC-4jlrH:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 4jlr MOTAVIZUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H   4
THR H   3
PHE H  27
ASP H  95
 None
 1.11A 2wm3A-4jlrH:
undetectable		 2wm3A-4jlrH:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 4jlr MOTAVIZUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H 112
ALA H 114
PHE H 146
LEU H 170
 None
 0.30A 5mthA-4jlrH:
26.8		 5mthA-4jlrH:
49.56