SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jlv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		3 / 3 GLU A1109
THR A1105
LEU A1122
 None
 0.67A 1v8bC-4jlvA:
2.4		 1v8bC-4jlvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 11 VAL A1180
ALA A1053
SER A1056
VAL A1059
ASP A1157
 None
ADP  A1301 (-3.9A)
MG  A1302 ( 2.6A)
None
MG  A1302 ( 4.7A)
 1.01A 2c12B-4jlvA:
undetectable		 2c12B-4jlvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_C_SPMC1434_1
(NITROALKANE OXIDASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 VAL A1180
ALA A1053
SER A1056
VAL A1059
ASP A1157
 None
ADP  A1301 (-3.9A)
MG  A1302 ( 2.6A)
None
MG  A1302 ( 4.7A)
 1.02A 2c12C-4jlvA:
undetectable		 2c12C-4jlvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 10 VAL A1180
ALA A1053
SER A1056
VAL A1059
ASP A1157
 None
ADP  A1301 (-3.9A)
MG  A1302 ( 2.6A)
None
MG  A1302 ( 4.7A)
 1.00A 2c12D-4jlvA:
undetectable		 2c12D-4jlvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 7 GLY A1136
ALA A1173
VAL A1144
ILE A1101
 None
 0.70A 3a2qA-4jlvA:
undetectable		 3a2qA-4jlvA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 8 GLU A1049
VAL A1208
LEU A1179
ALA A1053
 None
None
None
ADP  A1301 (-3.9A)
 1.01A 3ax7A-4jlvA:
undetectable		 3ax7A-4jlvA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 6 LEU A1143
PHE A1147
ILE A1111
THR A1105
 None
 0.95A 3mdrA-4jlvA:
undetectable		 3mdrA-4jlvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 GLY A1027
VAL A 214
LEU A1210
ILE A1021
PHE A1025
 None
 1.25A 3mnoA-4jlvA:
undetectable		 3mnoA-4jlvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 GLY A1027
VAL A 214
LEU A1210
ILE A1021
PHE A1025
 None
 1.23A 3mnpA-4jlvA:
undetectable		 3mnpA-4jlvA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 7 GLU A1049
VAL A1208
LEU A1179
ALA A1053
 None
None
None
ADP  A1301 (-3.9A)
 1.01A 3uniA-4jlvA:
undetectable		 3uniA-4jlvA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 7 ALA A1067
TYR A1066
ILE A1154
ILE A1155
 None
 0.63A 4eatA-4jlvA:
2.8		 4eatA-4jlvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 8 SER A1048
GLU A1049
VAL A1058
THR A1057
 ADP  A1301 ( 4.5A)
None
None
ADP  A1301 (-3.8A)
 0.78A 4lnwA-4jlvA:
undetectable		 4lnwA-4jlvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 LEU A1044
ILE A1032
ILE A1028
GLY A1207
VAL A1058
 None
 0.86A 4nkvB-4jlvA:
undetectable		 4nkvB-4jlvA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 9 ALA A1196
ILE A 200
THR A1047
SER A1177
VAL A1208
 None
 1.08A 4r21B-4jlvA:
undetectable		 4r21B-4jlvA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_A_AG2A502_1
(HOMOSPERMIDINE
SYNTHASE)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 PRO A1160
VAL A1180
SER A1048
ASP A1077
THR A1084
 None
None
ADP  A1301 ( 4.5A)
None
MG  A1302 (-4.0A)
 1.38A 4xrgA-4jlvA:
1.4		 4xrgA-4jlvA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 7 LEU A1100
THR A1123
LEU A1122
THR A1112
THR A1105
 None
 1.22A 4z90A-4jlvA:
undetectable
4z90B-4jlvA:
undetectable
4z90C-4jlvA:
undetectable
4z90D-4jlvA:
undetectable
4z90E-4jlvA:
undetectable		 4z90A-4jlvA:
22.56
4z90B-4jlvA:
22.56
4z90C-4jlvA:
22.56
4z90D-4jlvA:
22.56
4z90E-4jlvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 6 SER A1203
GLU A1199
GLY A1078
ASP A1157
 None
None
None
MG  A1302 ( 4.7A)
 0.84A 5cdnA-4jlvA:
undetectable
5cdnB-4jlvA:
undetectable		 5cdnA-4jlvA:
19.50
5cdnB-4jlvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 6 SER A1203
GLU A1199
GLY A1078
ASP A1157
 None
None
None
MG  A1302 ( 4.7A)
 0.90A 5cdnR-4jlvA:
undetectable
5cdnS-4jlvA:
undetectable		 5cdnR-4jlvA:
19.50
5cdnS-4jlvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 GLY A1096
ILE A1101
LEU A1134
GLY A1103
PHE A1147
 None
 1.04A 5d4uA-4jlvA:
3.0		 5d4uA-4jlvA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		5 / 12 LEU A1100
LEU A1097
GLY A1096
GLY A1125
LEU A1074
 None
 1.20A 5uc1A-4jlvA:
undetectable		 5uc1A-4jlvA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1
(Staphylococcus
aureus) 		4 / 7 GLY A1125
ALA A1124
VAL A1075
LEU A1121
 None
 0.79A 6dwnB-4jlvA:
undetectable		 6dwnB-4jlvA:
12.55