SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jlw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.14A 1c8lA-4jlwA:
undetectable		 1c8lA-4jlwA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  92
LEU A 149
LEU A 152
VAL A  42
 None
 0.69A 1jgsA-4jlwA:
undetectable		 1jgsA-4jlwA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 348
VAL A 363
ALA A 201
THR A  71
LEU A 168
 None
 1.24A 1jipA-4jlwA:
undetectable		 1jipA-4jlwA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.14A 1l5qA-4jlwA:
undetectable		 1l5qA-4jlwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.15A 1l5qB-4jlwA:
undetectable		 1l5qB-4jlwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.14A 1l7xA-4jlwA:
undetectable		 1l7xA-4jlwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.13A 1l7xB-4jlwA:
undetectable		 1l7xB-4jlwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.50A 1muiA-4jlwA:
undetectable		 1muiA-4jlwA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 251
VAL A 256
CYH A 258
ALA A 182
 None
 1.24A 1mz9E-4jlwA:
undetectable		 1mz9E-4jlwA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 125
VAL A 127
TRP A 132
GLY A 122
 None
 1.33A 1ng8A-4jlwA:
undetectable		 1ng8A-4jlwA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 125
VAL A 127
TRP A 132
GLY A 130
 None
 1.39A 1ng8A-4jlwA:
undetectable		 1ng8A-4jlwA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 125
VAL A 127
TRP A 132
GLY A 122
 None
 1.33A 1ng8B-4jlwA:
undetectable		 1ng8B-4jlwA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 125
VAL A 127
TRP A 132
GLY A 130
 None
 1.39A 1ng8B-4jlwA:
undetectable		 1ng8B-4jlwA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.40A 1rl8A-4jlwA:
undetectable		 1rl8A-4jlwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 11 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.47A 1sdvB-4jlwA:
undetectable		 1sdvB-4jlwA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 171
ALA A 201
ASN A 345
LEU A 348
ALA A 204
 None
 1.11A 2aclE-4jlwA:
undetectable		 2aclE-4jlwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.40A 2avvB-4jlwA:
undetectable		 2avvB-4jlwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 165
LEU A 168
ILE A 359
ILE A 357
ALA A 351
 None
 1.01A 2bxcA-4jlwA:
undetectable		 2bxcA-4jlwA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 2f81A-4jlwA:
undetectable		 2f81A-4jlwA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.39A 2f81B-4jlwA:
undetectable		 2f81B-4jlwA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.39A 2ienB-4jlwA:
undetectable		 2ienB-4jlwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 193
GLY A 178
GLY A 301
ALA A 179
LEU A 209
 NAD  A 403 ( 4.1A)
None
NAD  A 403 ( 3.7A)
None
None
 1.07A 2plwA-4jlwA:
9.0		 2plwA-4jlwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ASN A 345
LEU A 165
MET A  84
MET A 349
 None
 1.14A 2w8yA-4jlwA:
undetectable		 2w8yA-4jlwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.39A 3cywA-4jlwA:
undetectable		 3cywA-4jlwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 3cywB-4jlwA:
undetectable		 3cywB-4jlwA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 3d1zB-4jlwA:
undetectable		 3d1zB-4jlwA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.39A 3d20B-4jlwA:
undetectable		 3d20B-4jlwA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.12A 3dd1A-4jlwA:
undetectable		 3dd1A-4jlwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.14A 3ddsA-4jlwA:
undetectable		 3ddsA-4jlwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.14A 3ddsB-4jlwA:
undetectable		 3ddsB-4jlwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.13A 3ddwA-4jlwA:
undetectable		 3ddwA-4jlwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ASN A   4
HIS A 393
ALA A 137
GLY A   6
 None
 1.15A 3ddwB-4jlwA:
undetectable		 3ddwB-4jlwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 PRO A 197
ALA A 201
ALA A 204
ILE A 171
 NAD  A 403 (-3.1A)
None
None
None
 0.76A 3dtuC-4jlwA:
undetectable
3dtuD-4jlwA:
undetectable		 3dtuC-4jlwA:
22.32
3dtuD-4jlwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 3ekpD-4jlwA:
undetectable		 3ekpD-4jlwA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 11 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.42A 3ektC-4jlwA:
undetectable		 3ektC-4jlwA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 11 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.42A 3ektD-4jlwA:
undetectable		 3ektD-4jlwA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.44A 3ekvA-4jlwA:
undetectable		 3ekvA-4jlwA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 VAL A  90
LYS A 151
HIS A  35
 None
 0.96A 3elzA-4jlwA:
undetectable		 3elzA-4jlwA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_1
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 175
ALA A 202
VAL A 216
LEU A 208
VAL A 190
ILE A 192
 None
 1.35A 3em3A-4jlwA:
undetectable		 3em3A-4jlwA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 134
TYR A 126
SER A  49
ILE A 390
SER A  43
 None
None
NAD  A 403 ( 3.0A)
None
None
 1.06A 3frqB-4jlwA:
undetectable		 3frqB-4jlwA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 223
ASP A  50
GLN A 338
 NAD  A 403 (-3.4A)
None
NAD  A 403 (-3.8A)
 0.88A 3lcvB-4jlwA:
3.5		 3lcvB-4jlwA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 3lzsB-4jlwA:
undetectable		 3lzsB-4jlwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 3lzuA-4jlwA:
undetectable		 3lzuA-4jlwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 11 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.45A 3nu3B-4jlwA:
undetectable		 3nu3B-4jlwA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 9 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 3nuoB-4jlwA:
undetectable		 3nuoB-4jlwA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 TYR A 303
GLY A 301
GLY A  48
SER A  49
ALA A 193
 None
NAD  A 403 ( 3.7A)
NAD  A 403 (-3.0A)
NAD  A 403 ( 3.0A)
NAD  A 403 ( 4.1A)
 1.13A 3ou7B-4jlwA:
6.2		 3ou7B-4jlwA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  48
ILE A 192
GLY A 301
ALA A 201
ALA A 202
 NAD  A 403 (-3.0A)
None
NAD  A 403 ( 3.7A)
None
None
 1.06A 3sueA-4jlwA:
undetectable		 3sueA-4jlwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  48
VAL A 389
ILE A 192
GLY A 301
ALA A 201
ALA A 202
 NAD  A 403 (-3.0A)
None
None
NAD  A 403 ( 3.7A)
None
None
 1.41A 3sufD-4jlwA:
undetectable		 3sufD-4jlwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 12 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.37A 3tkwA-4jlwA:
undetectable		 3tkwA-4jlwA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 199
ALA A 193
LEU A 224
GLY A 264
ASP A 261
 None
NAD  A 403 ( 4.1A)
None
NAD  A 403 ( 4.1A)
None
 1.00A 4dc3A-4jlwA:
4.8		 4dc3A-4jlwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 355
ASP A 164
GLU A 160
ASP A 361
 None
 1.11A 4fevB-4jlwA:
undetectable		 4fevB-4jlwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 355
ASP A 164
GLU A 160
ASP A 361
 None
 1.16A 4fewB-4jlwA:
undetectable		 4fewB-4jlwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1Q_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4g1qA-4jlwA:
1.0		 4g1qA-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 355
ASP A 164
GLU A 160
ASP A 361
 None
 1.15A 4gkhD-4jlwA:
undetectable		 4gkhD-4jlwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A  52
ILE A 171
ASP A 218
GLY A 196
GLY A 194
 NAD  A 403 (-3.8A)
None
NAD  A 403 (-2.7A)
NAD  A 403 (-3.2A)
NAD  A 403 (-3.7A)
 1.15A 4hfpB-4jlwA:
undetectable		 4hfpB-4jlwA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ID5_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4id5A-4jlwA:
undetectable		 4id5A-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFV_A_T27A601_1
(EXORIBONUCLEASE H,
P66 RT)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4ifvA-4jlwA:
0.7		 4ifvA-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFY_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4ifyA-4jlwA:
1.4		 4ifyA-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG3_A_T27A601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4ig3A-4jlwA:
undetectable		 4ig3A-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 330
LEU A 326
ALA A 329
 None
 0.67A 4ikiA-4jlwA:
undetectable		 4ikiA-4jlwA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFB_A_T27A607_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H,
EXORIBONUCLEA P66 RT)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 250
VAL A 256
VAL A 213
TYR A 191
PRO A 254
 None
 1.12A 4kfbA-4jlwA:
undetectable		 4kfbA-4jlwA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 4ll3B-4jlwA:
undetectable		 4ll3B-4jlwA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 10 GLY A 175
ALA A 202
VAL A 190
GLY A 298
ILE A 299
ILE A 192
 None
 1.41A 4ll3A-4jlwA:
undetectable		 4ll3A-4jlwA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 136
ILE A  46
ILE A 368
TYR A 377
 None
 1.17A 5dnuA-4jlwA:
undetectable		 5dnuA-4jlwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 GLN A 136
ILE A  46
ILE A 368
TYR A 377
 None
 1.17A 5dnvA-4jlwA:
undetectable		 5dnvA-4jlwA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 195
LEU A 200
TYR A 344
PHE A  94
GLY A 110
 None
None
None
NAD  A 403 (-4.6A)
None
 1.12A 5eshA-4jlwA:
undetectable		 5eshA-4jlwA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 237
TYR A 191
SER A 286
 NAD  A 403 ( 4.9A)
None
SO4  A 404 (-3.8A)
 0.68A 5iktA-4jlwA:
undetectable		 5iktA-4jlwA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A  99
CYH A 104
CYH A 101
 ZN  A 401 ( 4.9A)
ZN  A 401 (-2.2A)
ZN  A 401 (-2.3A)
 0.97A 5inzB-4jlwA:
undetectable		 5inzB-4jlwA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  48
ILE A 192
GLY A 301
ALA A 201
ALA A 202
 NAD  A 403 (-3.0A)
None
NAD  A 403 ( 3.7A)
None
None
 1.01A 6c2mD-4jlwA:
undetectable		 6c2mD-4jlwA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 134
LEU A  66
VAL A   7
GLY A 121
ASP A  50
 None
 1.15A 6gngA-4jlwA:
2.8		 6gngA-4jlwA:
22.54