SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		5 / 8 ALA E 266
LEU E 288
LYS E 348
GLU E 351
THR E 341
 None
 1.48A 1ie4B-4jm2E:
undetectable
1ie4D-4jm2E:
undetectable		 1ie4B-4jm2E:
16.46
1ie4D-4jm2E:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ARG E 350
VAL E 360
TRP E 395
 None
 1.19A 1qw6A-4jm2E:
undetectable		 1qw6A-4jm2E:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ARG E 350
VAL E 360
TRP E 395
 None
 1.13A 1qwcA-4jm2E:
undetectable		 1qwcA-4jm2E:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ARG E 350
VAL E 360
TRP E 395
 None
 1.13A 1vagA-4jm2E:
undetectable		 1vagA-4jm2E:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ARG E 350
VAL E 360
TRP E 395
 None
 1.07A 1zviA-4jm2E:
undetectable		 1zviA-4jm2E:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		4 / 4 VAL E 286
PHE E 353
VAL E 360
TRP E 395
 None
 1.26A 2y00A-4jm2E:
0.0		 2y00A-4jm2E:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 LEU E 483
ILE E 251
HIS E 249
GLY E 263
 None
 0.81A 3b9lA-4jm2E:
undetectable		 3b9lA-4jm2E:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 GLN E 203
ASP E 113
GLN E 428
 None
 0.90A 4aztA-4jm2E:
undetectable		 4aztA-4jm2E:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU E 452
GLY E 471
GLN E 258
LEU E 390
ILE E 272
 None
 1.24A 4p6xA-4jm2E:
undetectable		 4p6xA-4jm2E:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 ARG E 350
VAL E 360
TRP E 395
 None
 1.13A 5fvoA-4jm2E:
undetectable		 5fvoA-4jm2E:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4jm2 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE E 468
LEU E 452
ARG E 469
GLY E 471
 None
None
NAG  E 523 (-3.0A)
None
 1.09A 5o4yA-4jm2E:
undetectable		 5o4yA-4jm2E:
5.69