SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		4 / 5 GLU A 297
LEU A 303
LEU A 300
LEU A 302
 None
 1.01A 1np1A-4jmkA:
undetectable		 1np1A-4jmkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		5 / 12 ALA A 248
ILE A 250
PHE A 289
LEU A 221
ILE A 258
 SO4  A 501 (-3.8A)
SO4  A 501 (-4.6A)
None
None
None
 1.06A 1xozA-4jmkA:
undetectable		 1xozA-4jmkA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		5 / 11 SER A 228
LEU A 170
ILE A 256
ALA A 193
ARG A 207
 None
 1.40A 2v0mA-4jmkA:
undetectable		 2v0mA-4jmkA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		4 / 5 ILE A 283
SER A 284
PRO A 285
PHE A 287
 None
 1.11A 3bjwC-4jmkA:
undetectable		 3bjwC-4jmkA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		3 / 3 ASN A 214
GLU A 219
ARG A 252
 SO4  A 502 (-3.4A)
None
SO4  A 502 ( 3.7A)
 0.94A 3wxoA-4jmkA:
undetectable		 3wxoA-4jmkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		5 / 12 VAL A 276
ILE A 258
ILE A 256
SER A 251
LEU A 170
 None
None
None
SO4  A 501 (-4.4A)
None
 1.01A 4iv0A-4jmkA:
undetectable		 4iv0A-4jmkA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		5 / 12 VAL A 276
ILE A 258
ILE A 256
SER A 251
LEU A 170
 None
None
None
SO4  A 501 (-4.4A)
None
 1.05A 4mwzB-4jmkA:
undetectable		 4mwzB-4jmkA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens) 		3 / 3 ASP A 215
LEU A 170
ARG A 280
 SO4  A 501 (-3.6A)
None
None
 0.96A 5e8qA-4jmkA:
undetectable		 5e8qA-4jmkA:
19.64