SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		4 / 8 SER A1048
SER A1056
ASP A1079
LYS A1082
 None
 1.17A 1hwiB-4jmpA:
undetectable		 1hwiB-4jmpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		4 / 8 SER A1048
SER A1056
ASP A1079
LYS A1082
 None
 1.23A 1hwkA-4jmpA:
undetectable		 1hwkA-4jmpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		4 / 8 SER A1048
SER A1056
ASP A1079
LYS A1082
 None
 1.22A 1hwkC-4jmpA:
undetectable		 1hwkC-4jmpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		4 / 8 SER A1048
SER A1056
ASP A1079
LYS A1082
 None
 1.21A 1hwkD-4jmpA:
undetectable		 1hwkD-4jmpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		4 / 7 PRO A1051
PRO A1160
VAL A1161
GLU A1190
 None
 1.09A 2v41E-4jmpA:
undetectable
2v41F-4jmpA:
undetectable		 2v41E-4jmpA:
21.72
2v41F-4jmpA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		5 / 11 SER A1105
SER A1099
LEU A1074
SER A1098
LEU A1097
 None
 1.07A 2xn5A-4jmpA:
undetectable		 2xn5A-4jmpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		5 / 11 SER A1105
SER A1099
LEU A1147
SER A1098
LEU A1097
 None
 1.09A 2xn5A-4jmpA:
undetectable		 2xn5A-4jmpA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		4 / 7 THR A1158
ILE A1156
GLY A1078
ILE A1135
 None
 0.62A 2y7wC-4jmpA:
undetectable		 2y7wC-4jmpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		5 / 12 THR A1114
ILE A1112
ILE A1111
LEU A1122
VAL A1064
 None
 1.00A 2yvlB-4jmpA:
3.1		 2yvlB-4jmpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		5 / 10 SER A1113
LEU A1143
LEU A1074
ASN A1150
LEU A1148
 None
 1.01A 4yiaA-4jmpA:
undetectable		 4yiaA-4jmpA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		3 / 3 LEU A1206
ILE A1044
TYR A1071
 None
 0.67A 5uunB-4jmpA:
undetectable		 5uunB-4jmpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 4jmp C-TERMINAL FRAGMENT
OF CAPA, PROTEIN
TYROSINE KINASE
(Staphylococcus
aureus) 		5 / 10 VAL A1121
THR A1114
LEU A1011
ASN A1061
ILE A1088
 None
 1.23A 6d9hR-4jmpA:
undetectable		 6d9hR-4jmpA:
17.39