SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jnc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 7 PHE A 409
GLU A 269
TYR A 276
GLU A 446
 None
 1.46A 2aowA-4jncA:
2.3		 2aowA-4jncA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.93A 2hs1B-4jncA:
undetectable		 2hs1B-4jncA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 7 GLY A 266
GLY A 458
PHE A 405
PHE A 409
 None
 0.91A 2qwxA-4jncA:
undetectable
2qwxB-4jncA:
3.1		 2qwxA-4jncA:
21.85
2qwxB-4jncA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 7 LYS A 530
SER A 412
ASP A 521
ARG A 440
 None
 1.49A 2rk8B-4jncA:
undetectable		 2rk8B-4jncA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 11 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.93A 3el1A-4jncA:
undetectable		 3el1A-4jncA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 5 HIS A 265
ASP A 292
TYR A 296
PRO A 462
 None
 1.21A 3fo7A-4jncA:
undetectable		 3fo7A-4jncA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 5 HIS A 265
ASP A 292
TYR A 296
PRO A 462
 None
 1.17A 3h1xA-4jncA:
undetectable		 3h1xA-4jncA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 11 VAL A 534
THR A 526
ALA A 411
GLU A 414
SER A 412
 None
 1.45A 3kp5A-4jncA:
undetectable		 3kp5A-4jncA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 6 LEU A 514
GLU A 508
PRO A 512
ARG A 516
 None
 1.41A 3ltwA-4jncA:
undetectable		 3ltwA-4jncA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.86A 3nu3A-4jncA:
undetectable		 3nu3A-4jncA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 9 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.95A 3nuoB-4jncA:
undetectable		 3nuoB-4jncA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 GLY A 337
LEU A 358
SER A 357
PHE A 267
HIS A 524
 None
None
None
1LF  A 601 (-4.8A)
1LF  A 601 (-3.3A)
 1.38A 3pfgA-4jncA:
undetectable		 3pfgA-4jncA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.88A 3pwmA-4jncA:
undetectable		 3pwmA-4jncA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 GLY A 333
GLY A 338
GLY A 337
LEU A 263
VAL A 330
 None
 1.01A 4htfB-4jncA:
2.5		 4htfB-4jncA:
23.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		12 / 12 ASP A 335
TYR A 343
ILE A 363
PHE A 381
TYR A 383
PHE A 387
LEU A 408
LEU A 428
TYR A 466
LEU A 499
HIS A 524
TRP A 525
 1LF  A 601 (-2.6A)
None
None
1LF  A 601 (-4.5A)
1LF  A 601 (-4.4A)
None
1LF  A 601 (-4.5A)
None
1LF  A 601 (-4.5A)
1LF  A 601 (-4.6A)
1LF  A 601 (-3.3A)
None
 0.62A 4j03A-4jncA:
52.9		 4j03A-4jncA:
85.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J03_A_FVSA603_2
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 5 TRP A 336
SER A 374
GLN A 384
ASN A 472
 1LF  A 601 (-3.4A)
None
1LF  A 601 ( 4.1A)
None
 0.47A 4j03A-4jncA:
52.9		 4j03A-4jncA:
85.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.86A 4jecB-4jncA:
undetectable		 4jecB-4jncA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		3 / 3 ARG A 516
THR A 360
TRP A 342
 None
1LF  A 601 ( 4.0A)
None
 1.20A 4ug5A-4jncA:
undetectable		 4ug5A-4jncA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 8 ASN A 366
PRO A 367
MET A 369
TYR A 343
 None
 1.42A 4v2zB-4jncA:
undetectable		 4v2zB-4jncA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 8 ASN A 366
PRO A 367
MET A 369
TYR A 343
 None
 1.48A 4v30B-4jncA:
undetectable		 4v30B-4jncA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.92A 5e5kB-4jncA:
undetectable		 5e5kB-4jncA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 THR A 360
LEU A 358
LEU A 489
MET A 507
ILE A 511
 1LF  A 601 ( 4.0A)
None
None
None
None
 1.16A 5gs4A-4jncA:
undetectable		 5gs4A-4jncA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 10 LEU A 263
HIS A 265
ILE A 332
GLY A 333
GLY A 337
 None
 0.90A 5o96C-4jncA:
undetectable
5o96D-4jncA:
undetectable		 5o96C-4jncA:
20.91
5o96D-4jncA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.89A 5t8hB-4jncA:
undetectable		 5t8hB-4jncA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 VAL A 261
VAL A 330
GLY A 517
THR A 360
GLY A 338
 None
None
None
1LF  A 601 ( 4.0A)
None
 1.08A 6brdC-4jncA:
undetectable		 6brdC-4jncA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 10 GLY A 337
LEU A 340
CYH A 264
VAL A 352
ALA A 345
 None
 1.13A 6czmA-4jncA:
undetectable
6czmC-4jncA:
undetectable		 6czmA-4jncA:
21.56
6czmC-4jncA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.91A 6dh3B-4jncA:
undetectable		 6dh3B-4jncA:
15.52