SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 5 HIS A 378
GLU A 377
ALA A 435
SER A 437
 None
FE  A 601 ( 1.9A)
None
None
 1.39A 1errA-4jo0A:
undetectable
1errB-4jo0A:
undetectable		 1errA-4jo0A:
17.44
1errB-4jo0A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 11 GLY A 280
GLN A   6
GLY A 284
ASP A 168
ARG A 288
 None
 0.83A 1mxgA-4jo0A:
undetectable		 1mxgA-4jo0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		3 / 3 THR A 175
GLU A 171
HIS A  69
 None
 0.84A 1xwfA-4jo0A:
undetectable		 1xwfA-4jo0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		3 / 3 THR A 175
GLU A 171
HIS A  69
 None
 0.82A 1xwfB-4jo0A:
undetectable		 1xwfB-4jo0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		3 / 3 THR A 175
GLU A 171
HIS A  69
 None
 0.86A 1xwfC-4jo0A:
2.1		 1xwfC-4jo0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		3 / 3 THR A 175
GLU A 171
HIS A  69
 None
 0.82A 1xwfD-4jo0A:
undetectable		 1xwfD-4jo0A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 THR A 405
GLY A 460
SER A 461
GLY A 428
ILE A 439
 None
 1.17A 2b25B-4jo0A:
undetectable		 2b25B-4jo0A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 9 LEU A 186
PHE A 162
LEU A   4
ARG A   5
ILE A   8
 None
 1.22A 2f7aB-4jo0A:
undetectable		 2f7aB-4jo0A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 4 ALA A 334
VAL A 337
PHE A 142
THR A  28
 None
 1.38A 2pkkA-4jo0A:
undetectable		 2pkkA-4jo0A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 9 LEU A   4
GLU A 232
ILE A   8
GLY A 280
SER A   3
 None
 1.11A 2qmmA-4jo0A:
undetectable		 2qmmA-4jo0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 8 LEU A 341
LEU A 345
LEU A  24
PHE A 313
 None
 0.81A 2vcvP-4jo0A:
undetectable		 2vcvP-4jo0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 8 ARG A 384
SER A 461
VAL A 415
TYR A 412
 None
 1.15A 2y05A-4jo0A:
undetectable
2y05B-4jo0A:
undetectable		 2y05A-4jo0A:
21.27
2y05B-4jo0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 11 GLY A 460
GLY A 428
PHE A 374
HIS A 305
HIS A 258
 None
None
None
FE  A 601 ( 3.4A)
ACT  A 604 (-4.5A)
 1.28A 2y7kA-4jo0A:
undetectable		 2y7kA-4jo0A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 LEU A 458
ILE A 303
LEU A 301
ILE A 319
VAL A 492
 None
 1.02A 2ygnA-4jo0A:
undetectable		 2ygnA-4jo0A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4jo0 CMLA
(Streptomyces
venezuelae) 		3 / 3 TRP A  17
TRP A  78
THR A  82
 None
 1.35A 4bboB-4jo0A:
undetectable		 4bboB-4jo0A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 9 VAL A 369
VAL A 370
GLU A 360
VAL A 354
GLY A 388
 None
 1.18A 4fwdA-4jo0A:
undetectable		 4fwdA-4jo0A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 7 LEU A 390
ARG A 396
SER A 404
VAL A 478
 None
 1.19A 4klrA-4jo0A:
undetectable		 4klrA-4jo0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 9 TYR A  22
GLY A 340
LEU A 345
VAL A 328
VAL A 353
 None
 1.20A 4mjrA-4jo0A:
undetectable		 4mjrA-4jo0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		3 / 3 ASP A 309
ASP A 403
ASN A 459
 FE  A 602 (-2.2A)
FE  A 602 ( 2.6A)
None
 0.81A 4q5mA-4jo0A:
undetectable		 4q5mA-4jo0A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 10 TYR A  22
LEU A 443
LEU A  92
ALA A  95
ALA A  30
 None
 1.35A 4rn6A-4jo0A:
undetectable		 4rn6A-4jo0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 5 LEU A 473
TYR A 412
ALA A 401
ILE A 427
 None
 1.06A 4y03B-4jo0A:
undetectable		 4y03B-4jo0A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 7 LEU A 341
GLU A 144
GLY A 343
GLY A 342
 None
 0.85A 5a06B-4jo0A:
undetectable		 5a06B-4jo0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 GLY A 376
HIS A 378
VAL A 492
GLY A 460
LEU A 375
 None
 1.08A 5hg0B-4jo0A:
undetectable		 5hg0B-4jo0A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 6 ASP A 403
ILE A 432
ARG A 457
TYR A 440
 FE  A 602 ( 2.6A)
None
None
None
 1.46A 5igyA-4jo0A:
undetectable		 5igyA-4jo0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 ILE A 439
GLU A 377
MET A 311
LEU A 341
TYR A  22
 None
FE  A 601 ( 1.9A)
None
None
None
 1.24A 5mqtC-4jo0A:
undetectable		 5mqtC-4jo0A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 6 TYR A 140
ASP A 134
GLY A 132
PHE A 130
 None
 0.99A 5nooC-4jo0A:
undetectable		 5nooC-4jo0A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 LEU A 301
ILE A 303
ILE A 439
TYR A 440
HIS A 378
 None
 1.14A 5y2tB-4jo0A:
undetectable		 5y2tB-4jo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 5 HIS A 307
HIS A 378
PHE A 374
HIS A 305
 FE  A 601 ( 3.1A)
None
None
FE  A 601 ( 3.4A)
 0.93A 5zrdB-4jo0A:
undetectable		 5zrdB-4jo0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 7 ASN A 462
ASN A 406
GLU A 468
ARG A 467
 None
 0.95A 6b8kA-4jo0A:
undetectable		 6b8kA-4jo0A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 4jo0 CMLA
(Streptomyces
venezuelae) 		4 / 8 ASN A 462
ASN A 406
GLU A 468
ARG A 467
 None
 0.94A 6b94A-4jo0A:
undetectable		 6b94A-4jo0A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 10 GLY A 460
GLY A 428
THR A 405
ASN A 406
ILE A 407
 None
 1.10A 6exiA-4jo0A:
undetectable		 6exiA-4jo0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 10 GLY A 460
GLY A 428
THR A 405
ASN A 406
ILE A 407
 None
 1.08A 6exiB-4jo0A:
undetectable		 6exiB-4jo0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 GLY A 460
GLY A 428
THR A 405
ASN A 406
ILE A 407
 None
 1.11A 6exiC-4jo0A:
undetectable
6exiD-4jo0A:
undetectable		 6exiC-4jo0A:
11.14
6exiD-4jo0A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)		 4jo0 CMLA
(Streptomyces
venezuelae) 		5 / 12 GLY A 460
GLY A 428
THR A 405
ASN A 406
ILE A 407
 None
 1.08A 6exiC-4jo0A:
undetectable
6exiD-4jo0A:
undetectable		 6exiC-4jo0A:
11.14
6exiD-4jo0A:
11.14