SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jo2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 ASN L  30
ILE L  48
PHE L  71
GLY L  64
THR L  74
 None
 1.45A 1g60B-4jo2L:
undetectable		 1g60B-4jo2L:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_A_VIBA702_1
(THIAMIN
PYROPHOSPHOKINASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		5 / 9 TYR L 139
VAL L 195
SER L 176
SER L 161
ASN L 160
 None
 1.41A 2hh9A-4jo2L:
0.2
2hh9B-4jo2L:
0.2		 2hh9A-4jo2L:
22.12
2hh9B-4jo2L:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HH9_B_VIBB701_1
(THIAMIN
PYROPHOSPHOKINASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		5 / 9 VAL L 195
SER L 176
SER L 161
ASN L 160
TYR L 139
 None
 1.41A 2hh9A-4jo2L:
0.2
2hh9B-4jo2L:
0.2		 2hh9A-4jo2L:
22.12
2hh9B-4jo2L:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 159
VAL H 178
SER H 176
ASN H 190
ASN H 151
 None
 1.42A 2y03A-4jo2H:
undetectable		 2y03A-4jo2H:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 159
VAL H 178
SER H 176
ASN H 190
ASN H 151
 None
 1.47A 2y03B-4jo2H:
undetectable		 2y03B-4jo2H:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus;
Oryctolagus
cuniculus) 		5 / 12 PHE L  98
GLY L 100
VAL H  37
LEU L  89
PHE H  96
 None
 1.20A 2zzmA-4jo2L:
undetectable		 2zzmA-4jo2L:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 159
VAL H 178
SER H 176
ASN H 190
ASN H 151
 None
 1.43A 3nyaA-4jo2H:
undetectable		 3nyaA-4jo2H:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.14A 4d7hA-4jo2H:
undetectable		 4d7hA-4jo2H:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		4 / 5 TYR H  90
LEU H  79
LEU H  82
ARG H  66
 None
 1.28A 4em2A-4jo2H:
undetectable		 4em2A-4jo2H:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 GLN L 154
THR L 153
THR L 152
 None
 0.79A 4fu9A-4jo2L:
undetectable		 4fu9A-4jo2L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 GLN L 154
THR L 156
THR L 155
 None
 0.80A 4fu9A-4jo2L:
undetectable		 4fu9A-4jo2L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 GLN L 154
THR L 153
THR L 152
 None
 0.80A 4fufA-4jo2L:
undetectable		 4fufA-4jo2L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 GLN L 154
THR L 156
THR L 155
 None
 0.79A 4fufA-4jo2L:
undetectable		 4fufA-4jo2L:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.28A 4ug5A-4jo2H:
undetectable		 4ug5A-4jo2H:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.14A 4uglA-4jo2H:
undetectable		 4uglA-4jo2H:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 8 TYR L  92
GLY L  90
ILE L  21
GLY L  99
 None
 0.85A 5alcL-4jo2L:
21.3		 5alcL-4jo2L:
42.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.20A 5g6cA-4jo2H:
undetectable		 5g6cA-4jo2H:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 5 TYR L  92
TYR L  28
GLY L  91
GLY L  90
 None
 1.22A 5x7pA-4jo2L:
undetectable		 5x7pA-4jo2L:
11.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		4 / 4 VAL L  15
GLY L 108
ASP L 109
ASP L 169
 None
 0.24A 6cjkC-4jo2L:
27.5		 6cjkC-4jo2L:
82.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 11 VAL H 200
THR H 198
VAL H 204
ALA H 114
VAL H 148
 None
 1.15A 6dryA-4jo2H:
undetectable		 6dryA-4jo2H:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 LIGHT
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 TRP L 147
ILE L 117
GLU L 190
 None
 0.85A 6hcxA-4jo2L:
undetectable		 6hcxA-4jo2L:
14.55