SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jo3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		4 / 4 ALA H  88
ARG H  38
GLN H  39
GLU H  46
 None
 1.46A 1lqtB-4jo3H:
undetectable		 1lqtB-4jo3H:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 10 THR H  87
VAL H  12
ASP H  10
ILE H 110
VAL H 111
 None
 1.42A 2qboA-4jo3H:
undetectable		 2qboA-4jo3H:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.43A 2y03A-4jo3H:
undetectable		 2y03A-4jo3H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.47A 2y03B-4jo3H:
undetectable		 2y03B-4jo3H:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		4 / 5 LEU H 108
GLN H  39
THR H  89
GLU H 148
 None
 1.31A 3n58C-4jo3H:
undetectable		 3n58C-4jo3H:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.43A 3nyaA-4jo3H:
undetectable		 3nyaA-4jo3H:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.04A 4d7hA-4jo3H:
undetectable		 4d7hA-4jo3H:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 10 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.47A 4ldoA-4jo3H:
undetectable		 4ldoA-4jo3H:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.18A 4ug5A-4jo3H:
undetectable		 4ug5A-4jo3H:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.06A 4uglA-4jo3H:
undetectable		 4uglA-4jo3H:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 ARG H  66
THR H  61
TRP H  62
 None
 1.10A 5g6cA-4jo3H:
undetectable		 5g6cA-4jo3H:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 TYR H 100
TYR H  34
PHE H  58
ILE H  56
TYR H 100
 None
 1.44A 5zwrB-4jo3H:
undetectable		 5zwrB-4jo3H:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		3 / 3 TYR H  59
GLY H  65
THR H  68
 None
 0.10A 6cjkB-4jo3H:
27.7		 6cjkB-4jo3H:
84.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 11 VAL H 204
THR H 202
VAL H 208
ALA H 118
VAL H 152
 None
 1.11A 6dryA-4jo3H:
undetectable		 6dryA-4jo3H:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN
(Oryctolagus
cuniculus) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.44A 6h7mB-4jo3H:
undetectable		 6h7mB-4jo3H:
18.47