SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jo5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 8 VAL A 158
LEU A  56
TYR A 161
VAL A 124
 None
 1.05A 1fduB-4jo5A:
undetectable		 1fduB-4jo5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A  15
VAL A 167
TRP A 168
 None
 0.84A 3l8lA-4jo5A:
undetectable
3l8lB-4jo5A:
undetectable		 3l8lA-4jo5A:
5.33
3l8lB-4jo5A:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 8 SER A  16
GLY A  17
ALA A  48
GLY A  45
 None
 0.90A 5albL-4jo5A:
2.5		 5albL-4jo5A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		5 / 12 PHE A  39
ILE A 126
PHE A 113
LEU A 109
THR A  94
 None
 1.08A 5byjA-4jo5A:
undetectable		 5byjA-4jo5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 4jo5 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ARG A  57
PHE A  95
ILE A 111
THR A  55
 CL  A 205 (-3.2A)
None
None
None
 1.00A 5vceA-4jo5A:
undetectable		 5vceA-4jo5A:
16.02