SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jo8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4jo8 M157
(Murid
betaherpesvirus
1) 		4 / 7 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.79A 2qmzA-4jo8A:
undetectable
2qmzB-4jo8A:
undetectable		 2qmzA-4jo8A:
24.11
2qmzB-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 4jo8 M157
(Murid
betaherpesvirus
1) 		3 / 3 GLU A  49
VAL A 122
CYH A 121
 None
 1.02A 3fbxA-4jo8A:
0.1		 3fbxA-4jo8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4jo8 M157
(Murid
betaherpesvirus
1) 		4 / 5 VAL A 276
VAL A 205
ARG A 286
LYS A 255
 None
 1.48A 3rv5A-4jo8A:
undetectable
3rv5B-4jo8A:
undetectable		 3rv5A-4jo8A:
14.05
3rv5B-4jo8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jo8 M157
(Murid
betaherpesvirus
1) 		3 / 3 THR A 251
VAL A 218
GLU A 244
 None
 0.72A 3v4tA-4jo8A:
undetectable
3v4tD-4jo8A:
undetectable		 3v4tA-4jo8A:
22.72
3v4tD-4jo8A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jo8 M157
(Murid
betaherpesvirus
1) 		4 / 8 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.72A 4fglD-4jo8A:
undetectable		 4fglD-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jo8 M157
(Murid
betaherpesvirus
1) 		4 / 7 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.74A 4fglC-4jo8A:
undetectable		 4fglC-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 4jo8 M157
(Murid
betaherpesvirus
1) 		3 / 3 LYS A 103
ARG A  60
TRP A  73
 None
 0.99A 4i90A-4jo8A:
undetectable		 4i90A-4jo8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4jo8 M157
(Murid
betaherpesvirus
1) 		4 / 4 VAL A 241
THR A 242
GLU A 243
GLU A 244
 None
 1.17A 4l78A-4jo8A:
undetectable		 4l78A-4jo8A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4jo8 M157
(Murid
betaherpesvirus
1) 		4 / 6 GLY A 170
GLN A 102
PHE A  98
ILE A 101
 None
 0.96A 4qogA-4jo8A:
undetectable
4qogB-4jo8A:
undetectable		 4qogA-4jo8A:
24.11
4qogB-4jo8A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jo8 KILLER CELL
LECTIN-LIKE RECEPTOR
8
M157
(Murid
betaherpesvirus
1;
Mus
musculus) 		5 / 12 ILE B 116
GLY A 172
GLY A 170
LEU A 109
THR A  53
 None
 1.08A 5eqbA-4jo8B:
undetectable		 5eqbA-4jo8B:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4jo8 M157
(Murid
betaherpesvirus
1) 		3 / 3 TYR A 138
ASP A 156
ASP A 136
 None
 0.85A 5x6yA-4jo8A:
undetectable		 5x6yA-4jo8A:
14.89