SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4joc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
5 / 10 GLU A 171
ARG A 174
LEU A 124
LEU A  81
PHE A 167
None
1.26A 1cmcA-4jocA:
undetectable
1cmcB-4jocA:
undetectable
1cmcA-4jocA:
15.05
1cmcB-4jocA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
5 / 10 LEU A 376
ILE A 347
TYR A 378
LEU A 341
VAL A  56
None
1.17A 1cqpA-4jocA:
undetectable
1cqpB-4jocA:
undetectable
1cqpA-4jocA:
18.37
1cqpB-4jocA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
5 / 12 PHE A 167
GLU A 171
ARG A 174
LEU A 124
LEU A  81
None
1.28A 1mj2A-4jocA:
undetectable
1mj2B-4jocA:
undetectable
1mj2A-4jocA:
15.05
1mj2B-4jocA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
4 / 7 ASP A 194
ILE A 307
ASN A 311
PHE A 160
None
1.15A 2jc9A-4jocA:
undetectable
2jc9A-4jocA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
4 / 6 ARG A 386
PRO A 203
GLY A 302
MET A 299
None
1.41A 3aqiA-4jocA:
undetectable
3aqiA-4jocA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB4_0
(FERROCHELATASE)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
4 / 6 ARG A 386
PRO A 203
GLY A 302
MET A 299
None
1.38A 3aqiB-4jocA:
undetectable
3aqiB-4jocA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
5 / 12 GLN A 131
GLY A 128
SER A 172
ARG A 168
ALA A 333
None
None
None
MLA  A 501 (-3.7A)
None
1.09A 3keeB-4jocA:
undetectable
3keeB-4jocA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
4 / 8 GLY A 136
ILE A 161
PHE A 304
PHE A  57
None
0.77A 3ko0K-4jocA:
undetectable
3ko0S-4jocA:
undetectable
3ko0K-4jocA:
14.21
3ko0S-4jocA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
4 / 7 ARG A 326
ILE A 161
LEU A 180
THR A 360
None
1.12A 3nxuA-4jocA:
undetectable
3nxuA-4jocA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
5 / 12 ASP A 293
ARG A 218
SER A 223
ILE A 228
PHE A 250
None
1.05A 3ua1A-4jocA:
undetectable
3ua1A-4jocA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
3 / 3 TYR A 412
MET A 343
LEU A 289
None
1.01A 3vw1D-4jocA:
undetectable
3vw1D-4jocA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
3 / 3 ARG A 219
ASP A 248
ASP A 254
None
0.88A 4kicB-4jocA:
undetectable
4kicB-4jocA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo
sapiens)
4 / 7 LEU A 407
GLU A 295
SER A 210
THR A 215
None
1.06A 4wnvD-4jocA:
undetectable
4wnvD-4jocA:
23.11