SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4joi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 4joi CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens) 		5 / 11 GLU D  78
GLY D  77
ARG D 113
LEU D  11
GLU D  14
 None
 1.45A 1mjqA-4joiD:
undetectable
1mjqB-4joiD:
undetectable		 1mjqA-4joiD:
22.50
1mjqB-4joiD:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 4joi CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens) 		5 / 11 ALA D  91
VAL D  42
ILE D  74
VAL D  55
VAL D  57
 None
 0.89A 2nnpB-4joiD:
undetectable		 2nnpB-4joiD:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 4joi CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		3 / 3 CYH A  88
HIS A 148
PHE A  72
 None
 0.95A 3cr4X-4joiA:
undetectable		 3cr4X-4joiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4joi CST COMPLEX SUBUNIT
STN1
CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens) 		4 / 4 ILE A 138
ARG D 119
ILE A  54
THR A 140
 None
 1.27A 3ia4C-4joiA:
undetectable		 3ia4C-4joiA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 4joi CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens) 		5 / 10 ALA D  91
VAL D  42
ILE D  74
VAL D  55
VAL D  57
 None
 0.95A 3nu9B-4joiD:
undetectable		 3nu9B-4joiD:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4joi CST COMPLEX SUBUNIT
STN1
CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens;
Homo
sapiens) 		5 / 10 TYR D 115
LEU A 170
LEU A  29
TYR A  49
TYR A 178
 None
 1.41A 5hwkA-4joiD:
undetectable		 5hwkA-4joiD:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 4joi CST COMPLEX SUBUNIT
STN1
CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens;
Homo
sapiens) 		5 / 10 TYR D 115
LEU A 170
LEU A  29
TYR A  49
TYR A 178
 None
 1.40A 5hwkB-4joiD:
undetectable		 5hwkB-4joiD:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 4joi CST COMPLEX SUBUNIT
STN1
CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 VAL D  93
THR D  25
GLY D  77
GLY A  76
ILE A  31
 None
 0.90A 5tuiB-4joiD:
undetectable		 5tuiB-4joiD:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4joi CST COMPLEX SUBUNIT
TEN1
(Homo
sapiens) 		5 / 12 ALA D  91
VAL D  42
ILE D  74
VAL D  55
VAL D  57
 None
 0.98A 6dh0A-4joiD:
undetectable		 6dh0A-4joiD:
16.39