SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4joq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		6 / 12 PHE A 297
VAL A 135
THR A 283
VAL A  95
ILE A 276
THR A 119
 None
 1.26A 3czhA-4joqA:
undetectable		 3czhA-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		6 / 12 VAL A 135
ALA A 136
THR A 283
VAL A  95
ILE A 276
THR A 119
 None
 1.23A 3czhA-4joqA:
undetectable		 3czhA-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 297
VAL A 135
VAL A  95
ILE A 276
THR A 119
 None
 1.12A 3dl9A-4joqA:
undetectable		 3dl9A-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 VAL A 135
ALA A 136
VAL A  95
ILE A 276
THR A 119
 None
 1.11A 3dl9A-4joqA:
undetectable		 3dl9A-4joqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 218
MET A 231
ILE A 234
ARG A 239
ALA A 267
 None
 1.42A 3lbdA-4joqA:
undetectable		 3lbdA-4joqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		3 / 3 ILE A  32
MET A  85
ARG A  89
 None
 0.93A 4lnxA-4joqA:
undetectable		 4lnxA-4joqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 LEU A 104
LEU A  97
VAL A  96
PHE A  99
 None
 1.21A 4uswA-4joqA:
undetectable		 4uswA-4joqA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		4 / 5 GLY A 143
ARG A 144
GLY A 147
GLU A 148
 None
 0.99A 4z2eB-4joqA:
undetectable
4z2eC-4joqA:
4.0		 4z2eB-4joqA:
20.56
4z2eC-4joqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_B_FOLB201_0
(FOLATE ECF
TRANSPORTER)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 MET A  85
ALA A  35
PHE A  67
THR A  31
THR A 283
 None
 1.45A 4z7fB-4joqA:
0.0		 4z7fB-4joqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ALA A 218
GLY A 143
LEU A 154
GLY A 248
VAL A 269
 None
 0.96A 5i73A-4joqA:
undetectable		 5i73A-4joqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 GLY A  42
PHE A 319
LEU A 265
ARG A 199
ASP A 225
 None
 1.48A 5nknA-4joqA:
undetectable		 5nknA-4joqA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		4 / 6 PRO A  98
LEU A  97
PHE A  99
LEU A 104
 None
 0.87A 5tl8A-4joqA:
undetectable		 5tl8A-4joqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		4 / 4 GLY A 124
LEU A 125
VAL A 120
GLU A 131
 None
 1.39A 5yw0A-4joqA:
undetectable		 5yw0A-4joqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 12 ASP A 225
ARG A 174
ALA A 222
GLY A 250
VAL A 269
 None
ACT  A 401 (-3.1A)
None
None
None
 1.12A 6clxA-4joqA:
undetectable		 6clxA-4joqA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4joq ABC RIBOSE
TRANSPORTER,
PERIPLASMIC
SOLUTE-BINDING
PROTEIN
(Rhodobacter
sphaeroides) 		5 / 11 PHE A  67
ILE A  34
LEU A 104
ASP A  81
ALA A  72
 None
 1.28A 6r2eF-4joqA:
undetectable		 6r2eF-4joqA:
19.40