SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jos'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 12 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.51A 1jdvE-4josA:
22.8
1jdvF-4josA:
22.3		 1jdvE-4josA:
23.08
1jdvF-4josA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.50A 1odiA-4josA:
17.0		 1odiA-4josA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.58A 1odiB-4josA:
24.6		 1odiB-4josA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.54A 1odiC-4josA:
24.4		 1odiC-4josA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.56A 1odiD-4josA:
24.6		 1odiD-4josA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.57A 1odiE-4josA:
24.6		 1odiE-4josA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.57A 1odiF-4josA:
24.5		 1odiF-4josA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 9 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.60A 1pk7A-4josA:
23.4		 1pk7A-4josA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 10 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.55A 1pk7C-4josA:
24.2		 1pk7C-4josA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 10 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.50A 1pk9A-4josA:
23.4		 1pk9A-4josA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 9 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.51A 1pk9B-4josA:
23.6		 1pk9B-4josA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.44A 1pk9C-4josA:
24.3		 1pk9C-4josA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 10 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.59A 1pw7A-4josA:
23.5		 1pw7A-4josA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 9 GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.55A 1pw7C-4josA:
24.1		 1pw7C-4josA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 10 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.60A 1z35A-4josA:
23.3		 1z35A-4josA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 9 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.47A 1z37A-4josA:
23.2		 1z37A-4josA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-2.8A)
 0.49A 2ac7A-4josA:
23.0
2ac7B-4josA:
23.0		 2ac7A-4josA:
24.72
2ac7B-4josA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-2.8A)
 0.49A 2ac7A-4josA:
23.0
2ac7B-4josA:
23.0		 2ac7A-4josA:
24.72
2ac7B-4josA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 GLY A   8
GLY A  76
GLU A  13
ALA A  47
GLU A 171
 None
 1.14A 2vdvE-4josA:
undetectable		 2vdvE-4josA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A   8
GLY A  76
GLU A  13
ALA A  47
GLU A 171
 None
 1.15A 2vdvF-4josA:
undetectable		 2vdvF-4josA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 9 GLY A   8
ALA A   9
ILE A  51
MET A 172
GLY A 174
ILE A 190
 None
None
None
ADE  A 301 (-4.1A)
None
None
 1.30A 3ogpB-4josA:
undetectable		 3ogpB-4josA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		4 / 5 ASP A 196
SER A 195
VAL A  77
GLY A  79
 ADE  A 301 (-2.8A)
ADE  A 301 (-3.3A)
None
ADE  A 301 (-3.7A)
 1.02A 3rxhA-4josA:
undetectable		 3rxhA-4josA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		3 / 3 TYR A  24
LEU A 224
LYS A 223
 None
 0.76A 3sueD-4josA:
undetectable		 3sueD-4josA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_C_ADNC251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 GLY A  79
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-2.8A)
 0.44A 3u40B-4josA:
23.1
3u40C-4josA:
15.1		 3u40B-4josA:
25.00
3u40C-4josA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_D_ADND251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-2.8A)
 0.45A 3u40D-4josA:
23.2
3u40E-4josA:
23.0		 3u40D-4josA:
25.00
3u40E-4josA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U40_E_ADNE251_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 GLY A  79
GLU A 171
MET A 172
GLU A 173
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-2.8A)
 0.45A 3u40D-4josA:
23.2
3u40E-4josA:
23.0		 3u40D-4josA:
25.00
3u40E-4josA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.47A 3uawA-4josA:
23.9		 3uawA-4josA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.42A 4d9hA-4josA:
24.1		 4d9hA-4josA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 10 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.43A 4da7A-4josA:
24.2		 4da7A-4josA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.76A 4danA-4josA:
13.3		 4danA-4josA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 12 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
ASP A 196
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
ADE  A 301 (-2.8A)
 0.76A 4danA-4josA:
13.3
4danB-4josA:
23.9		 4danA-4josA:
26.47
4danB-4josA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 GLY A   8
GLY A  76
ILE A  17
ALA A 218
MET A  10
 None
 1.07A 4kicA-4josA:
undetectable		 4kicA-4josA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 THR A  95
THR A 147
ALA A 175
GLY A 143
ALA A  92
 None
 1.22A 4qvnV-4josA:
undetectable
4qvnb-4josA:
undetectable		 4qvnV-4josA:
20.69
4qvnb-4josA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 THR A  95
THR A 147
ALA A 175
GLY A 143
ALA A  92
 None
 1.21A 4qvnH-4josA:
undetectable
4qvnN-4josA:
undetectable		 4qvnH-4josA:
20.69
4qvnN-4josA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 9 LEU A   7
GLY A   8
ILE A  62
LEU A  58
THR A  59
 None
 1.19A 4x3mB-4josA:
undetectable		 4x3mB-4josA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 11 GLY A  79
GLU A 171
MET A 172
GLU A 173
SER A 195
 ADE  A 301 (-3.7A)
None
ADE  A 301 (-4.1A)
None
ADE  A 301 (-3.3A)
 0.52A 5i3cC-4josA:
23.7		 5i3cC-4josA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 ILE A 170
GLY A  79
ASP A  99
HIS A  98
ILE A  51
 ADE  A 301 ( 4.9A)
ADE  A 301 (-3.7A)
None
None
None
 1.34A 5igwA-4josA:
undetectable		 5igwA-4josA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 ALA A  91
GLY A 143
ASP A 219
LEU A 136
LEU A 138
 None
 1.13A 5wwsA-4josA:
undetectable		 5wwsA-4josA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		6 / 12 GLY A  76
ILE A 190
VAL A 177
ILE A  14
LEU A   7
LEU A  72
 None
 1.33A 5wy0A-4josA:
undetectable		 5wy0A-4josA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		4 / 8 ILE A 228
LEU A  73
ALA A  91
LEU A 140
 None
 0.69A 5y7pE-4josA:
undetectable		 5y7pE-4josA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 THR A  95
VAL A 161
HIS A  98
VAL A 152
GLY A  79
 None
None
None
ADE  A 301 (-4.2A)
ADE  A 301 (-3.7A)
 1.32A 6gngB-4josA:
2.8		 6gngB-4josA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 THR A  95
THR A 147
ALA A 175
GLY A 143
ALA A  92
 None
 1.17A 6hwdV-4josA:
undetectable
6hwdb-4josA:
undetectable		 6hwdV-4josA:
15.85
6hwdb-4josA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE
(Francisella
philomiragia) 		5 / 12 THR A  95
THR A 147
ALA A 175
GLY A 143
ALA A  92
 None
 1.17A 6hwdH-4josA:
undetectable
6hwdN-4josA:
undetectable		 6hwdH-4josA:
15.85
6hwdN-4josA:
15.90