SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 MET A 107
THR A   9
ALA A  25
LEU A 124
LEU A  48
 None
 1.18A 1eiiA-4jotA:
undetectable		 1eiiA-4jotA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 11 ALA A 126
LEU A 158
LEU A 122
ILE A 177
ALA A 182
 None
 0.99A 1ha2A-4jotA:
2.5		 1ha2A-4jotA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 GLU A 190
ILE A 110
ILE A  58
ARG A 201
ALA A 200
 None
 1.39A 1ki7B-4jotA:
undetectable		 1ki7B-4jotA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 VAL A  59
LEU A  27
LEU A 105
LEU A  57
PHE A  40
 None
 0.97A 1mx1D-4jotA:
2.5		 1mx1D-4jotA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 PHE A  40
LEU A  29
LEU A 102
LEU A  48
PRO A  45
 None
 1.50A 1p33A-4jotA:
undetectable		 1p33A-4jotA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 10 LEU A 124
ALA A 128
ILE A 125
ALA A 202
PHE A  65
 None
 1.15A 1xp0A-4jotA:
undetectable		 1xp0A-4jotA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 GLY A 153
GLY A 154
LEU A 141
SER A 140
LEU A 187
 None
 0.90A 1ya4A-4jotA:
2.4		 1ya4A-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 GLY A 153
GLY A 154
LEU A 141
SER A 140
LEU A 187
 None
 0.83A 1ya4C-4jotA:
undetectable		 1ya4C-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 GLY A 153
LEU A 141
SER A 140
LEU A 124
LEU A 187
 None
 1.02A 1ya4C-4jotA:
undetectable		 1ya4C-4jotA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 LEU A 158
LEU A 122
ALA A 176
ILE A 177
ALA A 182
 None
 1.00A 2bxcA-4jotA:
undetectable		 2bxcA-4jotA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_F_BCZF1001_0
(NEURAMINIDASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 LEU A 141
ARG A 157
GLU A 123
ALA A 103
GLU A 100
 None
 1.50A 3k39F-4jotA:
undetectable		 3k39F-4jotA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_N_BCZN1001_0
(NEURAMINIDASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 LEU A 141
ARG A 157
GLU A 123
ALA A 103
GLU A 100
 None
 1.49A 3k39N-4jotA:
undetectable		 3k39N-4jotA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 7 GLY A 119
MET A  95
PHE A  44
PHE A  40
 None
 0.96A 3ko0D-4jotA:
undetectable
3ko0E-4jotA:
undetectable		 3ko0D-4jotA:
14.39
3ko0E-4jotA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 11 GLY A 119
GLU A 143
LEU A 152
LEU A 124
LEU A  69
 None
 1.27A 3ndvA-4jotA:
undetectable
3ndvB-4jotA:
undetectable		 3ndvA-4jotA:
24.93
3ndvB-4jotA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 11 LEU A  69
GLY A 119
GLU A 143
LEU A 152
LEU A 124
 None
 1.25A 3ndvC-4jotA:
undetectable
3ndvD-4jotA:
undetectable		 3ndvC-4jotA:
24.93
3ndvD-4jotA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 11 LEU A 124
PHE A  44
LEU A  29
ILE A   6
SER A   5
 None
 1.50A 3o94C-4jotA:
undetectable		 3o94C-4jotA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 PHE A  44
GLY A 121
PHE A  65
ALA A 126
ARG A 157
 None
 0.99A 4a6dA-4jotA:
undetectable		 4a6dA-4jotA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 12 PHE A  44
GLY A 121
PHE A  65
ALA A 126
ARG A 157
 None
 1.10A 4a6eA-4jotA:
undetectable		 4a6eA-4jotA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 8 LEU A   8
THR A  23
ALA A  25
LEU A  27
 None
 0.75A 4ik6B-4jotA:
undetectable		 4ik6B-4jotA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 11 LEU A 170
LEU A 122
ARG A 166
CYH A 117
VAL A 113
 None
 1.33A 4mk4B-4jotA:
undetectable		 4mk4B-4jotA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 GLY A  37
PRO A  38
GLN A   4
 None
 0.47A 4oltB-4jotA:
undetectable		 4oltB-4jotA:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		3 / 3 GLY A  37
PRO A  38
GLN A   4
 None
 0.42A 4qwpB-4jotA:
undetectable		 4qwpB-4jotA:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		5 / 10 GLY A 147
ALA A 171
VAL A 144
GLU A 143
GLU A 123
 None
 1.04A 5i3cB-4jotA:
2.0		 5i3cB-4jotA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4jot ENOYL-COA HYDRATASE,
PUTATIVE
(Deinococcus
radiodurans) 		4 / 7 VAL A 188
ARG A 201
GLU A 190
LEU A 209
 None
 1.17A 5umwB-4jotA:
undetectable
5umwE-4jotA:
undetectable		 5umwB-4jotA:
15.60
5umwE-4jotA:
15.60