SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 PHE A  46
TYR A  63
PRO A  35
 None
 1.16A 1mcnA-4joxA:
2.2
1mcnB-4joxA:
undetectable
1mcnP-4joxA:
undetectable		 1mcnA-4joxA:
20.83
1mcnB-4joxA:
20.83
1mcnP-4joxA:
0.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A  60
GLY A  59
GLY A  28
THR A  57
ILE A  61
 None
 0.96A 2akeA-4joxA:
undetectable		 2akeA-4joxA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A  60
GLY A  59
GLY A  28
THR A  57
ILE A  61
 None
 0.95A 2azxA-4joxA:
undetectable		 2azxA-4joxA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A  60
GLY A  59
GLY A  28
THR A  57
ILE A  61
 None
 1.00A 2azxB-4joxA:
undetectable		 2azxB-4joxA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A  65
ILE A  71
LEU A  18
ASN A  37
ASN A  66
 None
 1.26A 2nnhB-4joxA:
undetectable		 2nnhB-4joxA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 9 GLY A 101
GLY A 100
VAL A   6
HIS A 107
ASP A   9
 None
 1.42A 5f8yA-4joxA:
undetectable		 5f8yA-4joxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 8 GLY A 101
GLY A 100
VAL A   6
HIS A 107
ASP A   9
 None
 1.43A 5f8yA-4joxA:
undetectable		 5f8yA-4joxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 9 GLY A 101
GLY A 100
VAL A   6
HIS A 107
ASP A   9
 None
 1.41A 5f8yA-4joxA:
undetectable		 5f8yA-4joxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 8 GLY A 101
GLY A 100
VAL A   6
HIS A 107
ASP A   9
 None
 1.39A 5f8yB-4joxA:
undetectable		 5f8yB-4joxA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4jox 13.6 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 9 GLY A 101
GLY A 100
VAL A   6
HIS A 107
ASP A   9
 None
 1.41A 5f8yB-4joxA:
undetectable		 5f8yB-4joxA:
22.93