SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jp0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 LEU A 353
LEU A 356
ILE A 367
THR A 368
THR A 344
 None
 1.16A 1i18A-4jp0A:
undetectable
1i18B-4jp0A:
undetectable		 1i18A-4jp0A:
13.18
1i18B-4jp0A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 TRP A  47
TYR A  18
LEU A  32
 None
 1.04A 1kxhA-4jp0A:
undetectable		 1kxhA-4jp0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 LEU A 354
HIS A 359
ILE A 367
 None
 0.66A 1s9pB-4jp0A:
undetectable		 1s9pB-4jp0A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 TYR A   8
SER A 139
THR A 142
ASN A   5
 None
 1.45A 1yvpA-4jp0A:
undetectable		 1yvpA-4jp0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 HIS A 349
ASN A 301
THR A 374
PRO A 371
 None
 1.33A 2ez7A-4jp0A:
undetectable		 2ez7A-4jp0A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 SER A 284
THR A 235
GLN A 239
 None
 0.77A 2fk8A-4jp0A:
undetectable		 2fk8A-4jp0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 MET A 257
PHE A 259
TYR A 283
THR A 179
 None
 0.90A 2wx2A-4jp0A:
undetectable		 2wx2A-4jp0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		6 / 12 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
GLN A 332
 None
 1.36A 3eeyA-4jp0A:
undetectable		 3eeyA-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_B_SAMB300_0
(PUTATIVE RRNA
METHYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
 None
 1.06A 3eeyB-4jp0A:
undetectable		 3eeyB-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		6 / 12 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
GLN A 332
 None
 1.34A 3eeyF-4jp0A:
undetectable		 3eeyF-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		6 / 12 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
GLN A 332
 None
 1.37A 3eeyH-4jp0A:
undetectable		 3eeyH-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		6 / 12 THR A 335
GLY A 234
ASN A 338
ASP A 337
ILE A 237
GLN A 332
 None
 1.36A 3eeyI-4jp0A:
undetectable		 3eeyI-4jp0A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 8 PRO A 371
SER A 373
LEU A 378
LYS A 380
 None
 1.11A 3lsfH-4jp0A:
undetectable		 3lsfH-4jp0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 LEU A 318
ASP A 238
ILE A 237
GLY A 234
ILE A 333
 None
 1.13A 3s53B-4jp0A:
undetectable		 3s53B-4jp0A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 184
VAL A 186
PHE A  50
ILE A 143
ILE A 197
 None
 1.32A 3um5A-4jp0A:
undetectable		 3um5A-4jp0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 ILE A 184
VAL A 186
PHE A  50
ILE A 143
ILE A 197
 None
 1.32A 3um5B-4jp0A:
undetectable		 3um5B-4jp0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 TYR A  43
ASP A  41
ASP A  37
 None
 0.85A 5x6yA-4jp0A:
undetectable		 5x6yA-4jp0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4jp0 43.8 KDA
INSECTICIDAL CRYSTAL
PROTEIN
(Bacillus
thuringiensis) 		4 / 7 THR A 246
LEU A 247
THR A 268
TYR A 203
 None
 0.99A 5zsfA-4jp0A:
undetectable
5zsfB-4jp0A:
undetectable		 5zsfA-4jp0A:
9.97
5zsfB-4jp0A:
9.97