SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jpb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 4jpb CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		4 / 8 SER A 568
ARG A 594
ALA A 612
GLU A 609
 None
 1.06A 1dmiA-4jpbA:
undetectable
1dmiB-4jpbA:
undetectable		 1dmiA-4jpbA:
20.91
1dmiB-4jpbA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4jpb CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ILE A 585
ILE A 558
ILE A 566
THR A 565
VAL A 626
 None
 1.17A 2qo5A-4jpbA:
undetectable		 2qo5A-4jpbA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4jpb CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ILE A 544
ASP A 634
GLN A 632
ALA A 546
ILE A 558
 None
 1.09A 3ddyA-4jpbA:
undetectable		 3ddyA-4jpbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4jpb CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ILE A 635
ASP A 634
ALA A 546
ASN A 562
ILE A 558
 None
 1.03A 3ddyA-4jpbA:
undetectable		 3ddyA-4jpbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4jpb CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		5 / 12 ILE A 635
ASP A 634
GLN A 545
ALA A 546
ILE A 558
 None
 1.16A 3ddyA-4jpbA:
undetectable		 3ddyA-4jpbA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 4jpb CHEMOTAXIS PROTEIN
CHEA
(Thermotoga
maritima) 		4 / 4 VAL A 617
GLY A 618
ARG A 616
VAL A 615
 None
 1.41A 5d4nA-4jpbA:
undetectable
5d4nB-4jpbA:
undetectable		 5d4nA-4jpbA:
15.38
5d4nB-4jpbA:
15.38