SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 12 ILE A  51
ALA A  65
PHE A  44
ASN A  25
LEU A  33
 None
None
ACT  A 201 (-4.7A)
None
None
 1.29A 1u70A-4jpdA:
undetectable		 1u70A-4jpdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 12 ILE A  51
ILE A  63
ALA A  65
LEU A  42
ILE A 104
 None
 1.03A 2h79A-4jpdA:
undetectable		 2h79A-4jpdA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 12 PHE A  89
THR A  20
ALA A  16
ILE A 104
LEU A  40
 None
 1.12A 2rlcA-4jpdA:
undetectable		 2rlcA-4jpdA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		4 / 6 PHE A 106
LEU A  33
ALA A  24
ALA A  96
 None
 0.98A 2vcvB-4jpdA:
undetectable		 2vcvB-4jpdA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 12 ILE A  51
ALA A  65
PHE A  44
ASN A  25
LEU A  33
 None
None
ACT  A 201 (-4.7A)
None
None
 1.28A 2w3mB-4jpdA:
undetectable		 2w3mB-4jpdA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 12 ALA A  91
ILE A  63
PHE A 106
LEU A  42
ILE A 104
 None
 1.04A 2w3vA-4jpdA:
undetectable		 2w3vA-4jpdA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 12 ILE A  51
ILE A  63
ALA A  65
LEU A  42
ILE A 104
 None
 1.03A 3gwsX-4jpdA:
undetectable		 3gwsX-4jpdA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4jpd PROTEIN CYAY
(Burkholderia
cenocepacia) 		5 / 9 LEU A  92
ALA A  91
PHE A  88
VAL A  52
ILE A  50
 None
 1.12A 5om2A-4jpdA:
undetectable
5om2B-4jpdA:
undetectable		 5om2A-4jpdA:
19.67
5om2B-4jpdA:
15.18