SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		3 / 3 LEU A  24
PHE A  38
ARG A  81
 None
 0.66A 1xdkF-4jpkA:
undetectable		 1xdkF-4jpkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		4 / 4 SER A 166
TRP A 112
ASP A  47
ILE A  23
 None
 1.42A 2oxtD-4jpkA:
undetectable		 2oxtD-4jpkA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		5 / 12 SER A  16
PHE A 149
THR A 146
PRO A  11
GLY A 103
 NAG  A 201 (-4.9A)
None
None
None
None
 1.29A 3j6pB-4jpkA:
undetectable		 3j6pB-4jpkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A  19
THR A  20
PHE A  63
LEU A  91
LEU A  22
 None
 1.02A 4g1bB-4jpkA:
undetectable		 4g1bB-4jpkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		5 / 9 ILE A  19
THR A  20
PHE A  63
GLN A  90
LEU A  91
 None
 1.26A 4g1bC-4jpkA:
undetectable		 4g1bC-4jpkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		5 / 9 ILE A  19
THR A  20
PHE A  63
LEU A  91
LEU A  22
 None
 1.04A 4g1bC-4jpkA:
undetectable		 4g1bC-4jpkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_D_ECND403_1
(FLAVOHEMOGLOBIN)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A  19
THR A  20
PHE A  63
LEU A  91
LEU A  22
 None
 1.02A 4g1bD-4jpkA:
undetectable		 4g1bD-4jpkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		4 / 5 PHE A  38
ILE A 132
GLN A 126
ARG A  26
 None
 1.00A 5jm4A-4jpkA:
undetectable		 5jm4A-4jpkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		4 / 4 PHE A  38
ILE A 132
GLN A 126
ARG A  26
 None
 1.01A 5jm4B-4jpkA:
undetectable		 5jm4B-4jpkA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 4jpk GERMLINE-TARGETING
HIV-1 GP120
ENGINEERED OUTER
DOMAIN, EOD-GT6
(Human
immunodeficiency
virus
1) 		5 / 12 SER A  16
PHE A 149
THR A 146
PRO A  11
GLY A 103
 NAG  A 201 (-4.9A)
None
None
None
None
 1.28A 5ogcB-4jpkA:
undetectable		 5ogcB-4jpkA:
16.13