SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4jpw LIGHT CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.78A 1ictD-4jpwL:
3.4		 1ictD-4jpwL:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4jpw HEAVY CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  39
GLU H  46
 None
 1.49A 1lquB-4jpwH:
undetectable		 1lquB-4jpwH:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_A_SAMA1501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 4jpw HEAVY CHAIN OF
ANTIBODY 12A21
LIGHT CHAIN OF
ANTIBODY 12A21
(Homo
sapiens;
Homo
sapiens) 		4 / 7 TYR H 145
THR L 180
THR L 178
SER H 179
 None
 1.23A 1tv8A-4jpwH:
undetectable		 1tv8A-4jpwH:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4jpw LIGHT CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		3 / 3 GLY L  41
PRO L  40
ALA L  84
 None
 0.52A 4qn9B-4jpwL:
undetectable		 4qn9B-4jpwL:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 4jpw LIGHT CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		4 / 5 VAL L  19
ILE L  21
VAL L 104
THR L 102
 None
 0.76A 4xdtA-4jpwL:
undetectable		 4xdtA-4jpwL:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4jpw HEAVY CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		4 / 7 ARG H  66
GLN H  68
ILE H  67
GLY H  65
 None
 1.00A 5nzyA-4jpwH:
undetectable		 5nzyA-4jpwH:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 4jpw HEAVY CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		3 / 3 PRO H 185
SER H 187
SER H 188
 None
 0.67A 6bpyA-4jpwH:
undetectable		 6bpyA-4jpwH:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 4jpw HEAVY CHAIN OF
ANTIBODY 12A21
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.03A 6drzA-4jpwH:
undetectable		 6drzA-4jpwH:
18.29