SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1E6W_C_ESTC302_1 (SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE)	4jpz	FIBROBLAST GROWTH FACTOR 13 (Homo sapiens)	4 / 4	ALA A 60 GLN A 62 TYR A 69 LEU A 13	None	1.29A	1e6wC-4jpzA: undetectable	1e6wC-4jpzA: 22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQT_B_ACTB1873_0 (FPRA)	4jpz	FIBROBLAST GROWTH FACTOR 13 (Homo sapiens)	3 / 3	ASP A 43 ASP A 41 LYS A 19	None	1.12A	1lqtB-4jpzA: undetectable	1lqtB-4jpzA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LQU_B_ACTB1430_0 (FPRA)	4jpz	FIBROBLAST GROWTH FACTOR 13 (Homo sapiens)	3 / 3	ASP A 43 ASP A 41 LYS A 19	None	1.13A	1lquB-4jpzA: undetectable	1lquB-4jpzA: 17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TMZ_A_06XA504_1 (CYTOCHROME P450 2B4)	4jpz	FIBROBLAST GROWTH FACTOR 13 (Homo sapiens)	5 / 9	LEU A 70 LEU A 28 ILE A 16 PHE A 90 VAL A 59	None	1.47A	3tmzA-4jpzA: undetectable	3tmzA-4jpzA: 18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJU_A_TPVA500_2 (PROTEASE)	4jpz	FIBROBLAST GROWTH FACTOR 13 SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA (Homo sapiens)	5 / 10	LEU A 51 GLY B1849 PRO A 145 THR A 18 ILE A 16	None	0.94A	4njuB-4jpzA: undetectable	4njuB-4jpzA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJU_C_TPVC500_2 (PROTEASE)	4jpz	FIBROBLAST GROWTH FACTOR 13 SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA (Homo sapiens)	5 / 10	LEU A 51 GLY B1849 PRO A 145 THR A 18 ILE A 16	None	0.93A	4njuD-4jpzA: undetectable	4njuD-4jpzA: 19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4RN6_A_15UA301_1 (THROMBIN HEAVY CHAIN)	4jpz	SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA (Homo sapiens)	5 / 10	TRP B1802 LEU B1825 LEU B1844 ALA B1841 ALA B1860	None	1.46A	4rn6A-4jpzB: undetectable	4rn6A-4jpzB: 19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4S0V_A_SUVA2001_2 (HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE)	4jpz	FIBROBLAST GROWTH FACTOR 13 SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA (Homo sapiens)	4 / 5	ILE A 52 PRO A 53 HIS B1853 VAL A 100	None	1.27A	4s0vA-4jpzA: undetectable	4s0vA-4jpzA: 17.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1E6W_C_ESTC302_1","SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE","4jpz","FIBROBLAST GROWTH FACTOR 13","Homo sapiens",4,"ALA A  60;GLN A  62;TYR A  69;LEU A  13","None","1.29A","1e6wC-4jpzA:undetectable","1e6wC-4jpzA:22.05"],["1LQT_B_ACTB1873_0","FPRA","4jpz","FIBROBLAST GROWTH FACTOR 13","Homo sapiens",3,"ASP A  43;ASP A  41;LYS A  19","None","1.12A","1lqtB-4jpzA:undetectable","1lqtB-4jpzA:17.66"],["1LQU_B_ACTB1430_0","FPRA","4jpz","FIBROBLAST GROWTH FACTOR 13","Homo sapiens",3,"ASP A  43;ASP A  41;LYS A  19","None","1.13A","1lquB-4jpzA:undetectable","1lquB-4jpzA:17.66"],["3TMZ_A_06XA504_1","CYTOCHROME P450 2B4","4jpz","FIBROBLAST GROWTH FACTOR 13","Homo sapiens",5,"LEU A  70;LEU A  28;ILE A  16;PHE A  90;VAL A  59","None","1.47A","3tmzA-4jpzA:undetectable","3tmzA-4jpzA:18.04"],["4NJU_A_TPVA500_2","PROTEASE;PROTEASE","4jpz","FIBROBLAST GROWTH FACTOR 13;SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA","Homo sapiens",5,"LEU A  51;GLY B1849;PRO A 145;THR A  18;ILE A  16","None","0.94A","4njuB-4jpzA:undetectable","4njuB-4jpzA:19.35"],["4NJU_C_TPVC500_2","PROTEASE;PROTEASE","4jpz","FIBROBLAST GROWTH FACTOR 13;SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA","Homo sapiens",5,"LEU A  51;GLY B1849;PRO A 145;THR A  18;ILE A  16","None","0.93A","4njuD-4jpzA:undetectable","4njuD-4jpzA:19.35"],["4RN6_A_15UA301_1","THROMBIN HEAVY CHAIN","4jpz","SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA","Homo sapiens",5,"TRP B1802;LEU B1825;LEU B1844;ALA B1841;ALA B1860","None","1.46A","4rn6A-4jpzB:undetectable","4rn6A-4jpzB:19.11"],["4S0V_A_SUVA2001_2","HUMAN OREXIN RECEPTOR TYPE 2 FUSION PROTEIN TO P. ABYSII GLYCOGEN SYNTHASE","4jpz","FIBROBLAST GROWTH FACTOR 13;SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA","Homo sapiens",4,"ILE A  52;PRO A  53;HIS B1853;VAL A 100","None","1.27A","4s0vA-4jpzA:undetectable","4s0vA-4jpzA:17.25"]]