SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3A_A_TOPA1190_1 (DIHYDROFOLATE REDUCTASE)	4jq0	FIBROBLAST GROWTH FACTOR 12 (Homo sapiens)	5 / 11	ILE A 61 PHE A 141 ILE A 126 VAL A 70 THR A 18	None	1.11A	2w3aA-4jq0A: undetectable	2w3aA-4jq0A: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SPK_B_TPVB100_1 (HIV-1 PROTEASE)	4jq0	FIBROBLAST GROWTH FACTOR 12 SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA (Homo sapiens)	5 / 9	LEU A 51 VAL A 148 GLY D1845 PRO A 145 THR A 18	None	1.13A	3spkA-4jq0A: undetectable	3spkA-4jq0A: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJU_A_TPVA500_2 (PROTEASE)	4jq0	FIBROBLAST GROWTH FACTOR 12 SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA (Homo sapiens)	6 / 10	LEU A 51 VAL A 148 GLY D1845 PRO A 145 THR A 18 ILE A 16	None	1.19A	4njuB-4jq0A: undetectable	4njuB-4jq0A: 15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4NJU_C_TPVC500_2 (PROTEASE)	4jq0	FIBROBLAST GROWTH FACTOR 12 SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA (Homo sapiens)	6 / 10	LEU A 51 VAL A 148 GLY D1845 PRO A 145 THR A 18 ILE A 16	None	1.19A	4njuD-4jq0A: undetectable	4njuD-4jq0A: 15.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2W3A_A_TOPA1190_1","DIHYDROFOLATE REDUCTASE","4jq0","FIBROBLAST GROWTH FACTOR 12","Homo sapiens",5,"ILE A  61;PHE A 141;ILE A 126;VAL A  70;THR A  18","None","1.11A","2w3aA-4jq0A:undetectable","2w3aA-4jq0A:23.70"],["3SPK_B_TPVB100_1","HIV-1 PROTEASE;HIV-1 PROTEASE","4jq0","FIBROBLAST GROWTH FACTOR 12;SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA","Homo sapiens",5,"LEU A  51;VAL A 148;GLY D1845;PRO A 145;THR A  18","None","1.13A","3spkA-4jq0A:undetectable","3spkA-4jq0A:15.38"],["4NJU_A_TPVA500_2","PROTEASE;PROTEASE","4jq0","FIBROBLAST GROWTH FACTOR 12;SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA","Homo sapiens",6,"LEU A  51;VAL A 148;GLY D1845;PRO A 145;THR A  18;ILE A  16","None","1.19A","4njuB-4jq0A:undetectable","4njuB-4jq0A:15.51"],["4NJU_C_TPVC500_2","PROTEASE;PROTEASE","4jq0","FIBROBLAST GROWTH FACTOR 12;SODIUM CHANNEL PROTEIN TYPE 5 SUBUNIT ALPHA","Homo sapiens",6,"LEU A  51;VAL A 148;GLY D1845;PRO A 145;THR A  18;ILE A  16","None","1.19A","4njuD-4jq0A:undetectable","4njuD-4jq0A:15.51"]]