SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jqf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		4 / 8 LEU A 229
GLU A 230
GLU A 228
ILE A 271
 None
 1.10A 1qvtA-4jqfA:
1.8		 1qvtA-4jqfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		5 / 12 GLU A 191
ALA A 192
GLY A 197
LEU A 199
ALA A 190
 None
 1.31A 3ou6C-4jqfA:
undetectable		 3ou6C-4jqfA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		4 / 6 ALA A 239
ILE A 244
LEU A 204
ALA A 270
 None
 0.90A 3r9sC-4jqfA:
undetectable		 3r9sC-4jqfA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		4 / 5 LYS A 303
ILE A 304
HIS A 301
VAL A 347
 None
 0.95A 5jmnA-4jqfA:
undetectable		 5jmnA-4jqfA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		5 / 10 SER A 334
LEU A 351
LEU A 300
ASP A 299
ILE A 308
 None
 1.49A 6dm2B-4jqfA:
undetectable
6dm2C-4jqfA:
undetectable		 6dm2B-4jqfA:
21.88
6dm2C-4jqfA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4jqf CST COMPLEX SUBUNIT
STN1
(Homo
sapiens) 		5 / 10 ILE A 308
SER A 334
LEU A 351
LEU A 300
ASP A 299
 None
 1.49A 6dm2A-4jqfA:
undetectable
6dm2D-4jqfA:
undetectable		 6dm2A-4jqfA:
21.88
6dm2D-4jqfA:
21.88