SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jqp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 9 ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 0.96A 1hxwA-4jqpA:
undetectable		 1hxwA-4jqpA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		4 / 6 ASP A  87
LEU A  49
VAL A  50
ILE A  20
 None
 0.99A 1s9qA-4jqpA:
undetectable		 1s9qA-4jqpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		4 / 6 LEU A  49
VAL A  50
ILE A  51
TYR A  14
 None
 1.03A 1s9qA-4jqpA:
undetectable		 1s9qA-4jqpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		6 / 12 ALA A 339
ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 1.25A 3d1xA-4jqpA:
undetectable		 3d1xA-4jqpA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		6 / 12 ALA A 339
ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 1.31A 3d1yA-4jqpA:
undetectable		 3d1yA-4jqpA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		6 / 11 ALA A 339
ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 1.37A 3ekxB-4jqpA:
undetectable		 3ekxB-4jqpA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		3 / 3 SER A 327
ASP A 324
ASP A 310
 None
 0.71A 3iv6A-4jqpA:
undetectable		 3iv6A-4jqpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		3 / 3 SER A 327
ASP A 324
ASP A 310
 None
 0.67A 3iv6C-4jqpA:
2.4		 3iv6C-4jqpA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 9 ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 1.08A 3nu4A-4jqpA:
undetectable		 3nu4A-4jqpA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 9 ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 1.08A 3nuoA-4jqpA:
undetectable		 3nuoA-4jqpA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 12 GLY A  23
GLY A  29
ILE A  20
VAL A  33
ALA A 107
 None
 1.13A 4a6dA-4jqpA:
undetectable		 4a6dA-4jqpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 12 VAL A 323
GLU A  31
ASP A 310
HIS A 311
ALA A 314
 None
 1.33A 5hnzB-4jqpA:
undetectable		 5hnzB-4jqpA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		4 / 6 LEU A 329
CYH A  46
HIS A  39
LEU A  37
 None
 1.22A 5hrqD-4jqpA:
undetectable
5hrqG-4jqpA:
undetectable
5hrqH-4jqpA:
undetectable		 5hrqD-4jqpA:
7.69
5hrqG-4jqpA:
5.73
5hrqH-4jqpA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 12 LEU A 154
THR A 132
ILE A 130
GLY A  19
ILE A 127
 None
 1.04A 5ifuA-4jqpA:
2.7		 5ifuA-4jqpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 12 LEU A 274
ILE A 240
VAL A 218
GLY A 217
ILE A 216
 None
 0.80A 5j2tC-4jqpA:
undetectable		 5j2tC-4jqpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		6 / 12 ALA A 339
ASP A 128
GLY A 210
ILE A 211
VAL A 300
ILE A 305
 None
 1.27A 5kqxA-4jqpA:
undetectable		 5kqxA-4jqpA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 12 ASN A 222
GLY A 232
VAL A 177
VAL A 195
ILE A 240
 None
 0.97A 5vopA-4jqpA:
2.5		 5vopA-4jqpA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 4jqp 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Paraburkholderia
phymatum) 		5 / 12 ILE A 317
ALA A 314
ALA A 139
ALA A  26
ALA A  25
 None
 1.07A 5zw4A-4jqpA:
undetectable		 5zw4A-4jqpA:
22.61