SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jqt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 208
GLY A  70
LYS A  67
TYR A  69
 None
 1.39A 1gtiF-4jqtA:
undetectable		 1gtiF-4jqtA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 442
ASN A 230
ILE A 272
GLY A 271
 EDO  A 506 (-3.5A)
None
None
None
 1.07A 1oniA-4jqtA:
undetectable
1oniB-4jqtA:
undetectable		 1oniA-4jqtA:
14.49
1oniB-4jqtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASN A 442
ASN A 230
ILE A 272
GLY A 271
 EDO  A 506 (-3.5A)
None
None
None
 1.01A 1oniD-4jqtA:
undetectable
1oniF-4jqtA:
undetectable		 1oniD-4jqtA:
14.49
1oniF-4jqtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 272
GLY A 271
ASN A 442
ASN A 230
 None
None
EDO  A 506 (-3.5A)
None
 0.90A 1oniG-4jqtA:
undetectable
1oniI-4jqtA:
undetectable		 1oniG-4jqtA:
14.49
1oniI-4jqtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		6 / 12 GLY A 313
VAL A 302
LEU A 430
LEU A 431
LEU A 358
LEU A 300
 NA  A 502 ( 4.2A)
None
None
None
None
None
 1.32A 1ya4C-4jqtA:
undetectable		 1ya4C-4jqtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PRO A  59
THR A 198
VAL A 199
GLY A  52
 None
 1.14A 3elzA-4jqtA:
undetectable		 3elzA-4jqtA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 VAL A 443
ILE A 336
VAL A 438
VAL A 275
 None
 0.80A 3fi0B-4jqtA:
undetectable		 3fi0B-4jqtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP6_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A 349
ILE A 397
HIS A 389
VAL A 387
TYR A 316
 None
 1.28A 3sp6A-4jqtA:
undetectable		 3sp6A-4jqtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A  50
THR A  65
THR A  66
TYR A  69
 None
 0.90A 3tneB-4jqtA:
undetectable		 3tneB-4jqtA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 267
GLU A 269
TRP A 439
 None
 1.09A 3v4tH-4jqtA:
undetectable		 3v4tH-4jqtA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 119
ARG A 115
PHE A  78
ILE A 110
 None
 0.90A 4j4vC-4jqtA:
undetectable		 4j4vC-4jqtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 107
LEU A  90
GLY A 119
ALA A 142
ASN A 149
 NA  A 501 (-3.0A)
None
None
None
None
 1.19A 4pclB-4jqtA:
undetectable		 4pclB-4jqtA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A  69
LYS A  67
GLY A  33
LEU A  25
 None
None
EDO  A 503 (-3.6A)
None
 1.23A 5bphD-4jqtA:
undetectable		 5bphD-4jqtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 156
ILE A 182
ASN A 171
PHE A 108
 EDO  A 505 ( 4.4A)
None
None
None
 0.98A 5hieC-4jqtA:
undetectable		 5hieC-4jqtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 344
HIS A 434
ILE A 336
TYR A 415
 None
 1.21A 5ih0A-4jqtA:
undetectable		 5ih0A-4jqtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  45
LEU A  63
PHE A  26
THR A  66
ALA A  41
 None
 1.10A 5x66F-4jqtA:
undetectable		 5x66F-4jqtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 216
ARG A 161
GLN A  20
ASP A 203
 None
EDO  A 505 ( 3.6A)
None
None
 1.30A 6ectA-4jqtA:
undetectable		 6ectA-4jqtA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 216
ARG A 161
GLN A  20
ASP A 203
 None
EDO  A 505 ( 3.6A)
None
None
 1.27A 6ecxA-4jqtA:
undetectable		 6ecxA-4jqtA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 4jqt PUTATIVE GLYCOSYL
HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 185
LEU A 130
ASP A 174
ILE A 160
THR A 162
 NA  A 501 (-3.2A)
None
None
None
None
 1.06A 6fzbB-4jqtA:
undetectable		 6fzbB-4jqtA:
13.01