SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_E_TFPE212_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	4jra	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	4 / 7	PHE C 542 PHE C 507 PHE C 547 SER C 555	None	0.90A	1wrlE-4jraC: undetectable	1wrlE-4jraC: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R6W_A_NFZA213_1 (FMN-DEPENDENT NADH-AZOREDUCTASE 1)	4jra	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	5 / 10	PHE C 547 PHE C 552 VAL C 505 PHE C 502 PHE C 522	None	1.49A	3r6wA-4jraC: undetectable 3r6wB-4jraC: undetectable	3r6wA-4jraC: 19.55 3r6wB-4jraC: 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AP6_B_TLFB300_0 (PROBABLE STRIGOLACTONE ESTERASE DAD2)	4jra	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	5 / 12	PHE C 512 PHE C 542 VAL C 525 PHE C 502 PHE C 547	None	1.32A	6ap6B-4jraC: undetectable	6ap6B-4jraC: 15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HUO_D_08HD501_0 (GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOB UTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2)	4jra	SYNAPTIC VESICLE GLYCOPROTEIN 2C (Homo sapiens)	4 / 8	PHE C 532 PHE C 522 SER C 515 TYR C 497	None	1.16A	6huoC-4jraC: undetectable 6huoD-4jraC: undetectable	6huoC-4jraC: 20.90 6huoD-4jraC: 20.71

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WRL_E_TFPE212_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","4jra","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",4,"PHE C 542;PHE C 507;PHE C 547;SER C 555","None","0.90A","1wrlE-4jraC:undetectable","1wrlE-4jraC:18.84"],["3R6W_A_NFZA213_1","FMN-DEPENDENT NADH-AZOREDUCTASE 1;FMN-DEPENDENT NADH-AZOREDUCTASE 1","4jra","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",5,"PHE C 547;PHE C 552;VAL C 505;PHE C 502;PHE C 522","None","1.49A","3r6wA-4jraC:undetectable;3r6wB-4jraC:undetectable","3r6wA-4jraC:19.55;3r6wB-4jraC:19.55"],["6AP6_B_TLFB300_0","PROBABLE STRIGOLACTONE ESTERASE DAD2","4jra","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",5,"PHE C 512;PHE C 542;VAL C 525;PHE C 502;PHE C 547","None","1.32A","6ap6B-4jraC:undetectable","6ap6B-4jraC:15.93"],["6HUO_D_08HD501_0","GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT GAMMA-2","4jra","SYNAPTIC VESICLE GLYCOPROTEIN 2C","Homo sapiens",4,"PHE C 532;PHE C 522;SER C 515;TYR C 497","None","1.16A","6huoC-4jraC:undetectable;6huoD-4jraC:undetectable","6huoC-4jraC:20.90;6huoD-4jraC:20.71"]]