SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		3 / 3 ASN A 170
LEU A 141
HIS A 169
 None
 0.87A 2q6fB-4jrbA:
undetectable		 2q6fB-4jrbA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		4 / 6 ILE A 188
PHE A  83
ALA A  87
ASN A 185
 None
 1.14A 3pgyA-4jrbA:
undetectable
3pgyB-4jrbA:
undetectable		 3pgyA-4jrbA:
24.51
3pgyB-4jrbA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.15A 3t3rB-4jrbA:
undetectable		 3t3rB-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.19A 3t3rC-4jrbA:
undetectable		 3t3rC-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
CR2  A  66 ( 4.8A)
CR2  A  66 ( 3.6A)
None
None
 1.14A 3t3rD-4jrbA:
undetectable		 3t3rD-4jrbA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1478_0
(MJ0495-LIKE PROTEIN)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		4 / 7 ASP A  19
THR A 108
SER A  28
PHE A  27
 None
 1.04A 4ac9C-4jrbA:
undetectable		 4ac9C-4jrbA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		4 / 6 VAL A  55
LEU A  53
LEU A 125
PHE A 165
 None
None
None
CR2  A  66 ( 4.4A)
 1.01A 4o1zA-4jrbA:
undetectable		 4o1zA-4jrbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 12 PHE A1043
LEU A1044
GLY A1102
LEU A1036
GLN A1037
 D12  A1304 ( 4.1A)
None
None
None
None
 1.09A 4wnwB-4jrbA:
undetectable		 4wnwB-4jrbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		4 / 8 TYR A  92
PHE A  84
VAL A 163
ILE A 123
 None
 0.95A 5hw8H-4jrbA:
undetectable		 5hw8H-4jrbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		3 / 3 LYS A 140
ASN A 135
SER A 175
 None
 1.26A 5yw0A-4jrbA:
undetectable		 5yw0A-4jrbA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4jrb GREEN FLUORESCENT
PROTEIN
(Aequorea
victoria;
Blattella
germanica) 		5 / 12 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 4.0A)
None
None
None
CR2  A  66 ( 4.8A)
 1.24A 6bbsA-4jrbA:
undetectable		 6bbsA-4jrbA:
10.29