SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jrf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		5 / 10 ARG A 212
THR A 516
GLY A  99
VAL A  98
SER A  51
 None
 1.22A 1z35A-4jrfA:
undetectable		 1z35A-4jrfA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		5 / 12 ASN A 242
LEU A 241
ALA A 240
LEU A 470
THR A 486
 None
 1.34A 2aa5B-4jrfA:
undetectable		 2aa5B-4jrfA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		5 / 12 ASN A 242
LEU A 241
ALA A 240
LEU A 470
THR A 486
 None
 1.31A 2oaxF-4jrfA:
undetectable		 2oaxF-4jrfA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		3 / 3 THR A 487
SER A 280
LYS A 246
 PG4  A 614 (-3.6A)
None
None
 1.21A 3aocC-4jrfA:
undetectable		 3aocC-4jrfA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		4 / 7 PHE A 277
ASN A 283
PHE A 282
THR A 487
 None
None
None
PG4  A 614 (-3.6A)
 0.97A 3t3sC-4jrfA:
undetectable		 3t3sC-4jrfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		4 / 8 PHE A 277
ASN A 283
PHE A 282
THR A 487
 None
None
None
PG4  A 614 (-3.6A)
 0.89A 3t3sF-4jrfA:
undetectable		 3t3sF-4jrfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		4 / 5 ASP A 152
THR A 150
LEU A 151
LYS A 159
 None
 1.47A 4a3pA-4jrfA:
undetectable		 4a3pA-4jrfA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		3 / 3 TYR A 272
MET A 311
ILE A 445
 None
CA  A 601 ( 4.5A)
None
 0.76A 4c8bB-4jrfA:
undetectable		 4c8bB-4jrfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		3 / 3 TYR A 251
ARG A 267
SER A 252
 None
 0.95A 4dr2I-4jrfA:
undetectable
4dr2J-4jrfA:
undetectable		 4dr2I-4jrfA:
13.00
4dr2J-4jrfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		4 / 7 HIS A 446
ILE A 445
TYR A 468
HIS A 447
 PG4  A 617 ( 3.6A)
None
None
None
 1.20A 4g5jA-4jrfA:
undetectable		 4g5jA-4jrfA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		3 / 3 TYR A 251
ARG A 267
SER A 252
 None
 1.02A 4khpI-4jrfA:
undetectable
4khpJ-4jrfA:
undetectable		 4khpI-4jrfA:
12.77
4khpJ-4jrfA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		3 / 3 TYR A 251
ARG A 267
SER A 252
 None
 0.93A 4lf7I-4jrfA:
undetectable
4lf7J-4jrfA:
undetectable		 4lf7I-4jrfA:
13.00
4lf7J-4jrfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		3 / 3 TYR A 251
ARG A 267
SER A 252
 None
 0.93A 4lf8I-4jrfA:
undetectable
4lf8J-4jrfA:
undetectable		 4lf8I-4jrfA:
13.00
4lf8J-4jrfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		5 / 12 PRO A 484
GLU A 417
PHE A 434
SER A 419
GLY A 415
 None
 1.45A 4olfA-4jrfA:
undetectable		 4olfA-4jrfA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		5 / 12 PRO A 484
GLU A 417
PHE A 434
SER A 419
GLY A 415
 None
 1.48A 5xioA-4jrfA:
undetectable		 5xioA-4jrfA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4jrf PUTATIVE CELL
ADHESION PROTEIN
(Bacteroides
ovatus) 		5 / 9 SER A 298
PHE A 297
LEU A 293
VAL A 325
ASN A 242
 None
 1.34A 6ftpA-4jrfA:
undetectable
6ftpB-4jrfA:
undetectable		 6ftpA-4jrfA:
11.24
6ftpB-4jrfA:
5.94