SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jrl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		5 / 12 GLY A 248
LEU A 347
ILE A 345
ILE A 372
LEU A 371
 None
 1.14A 1kyvA-4jrlA:
undetectable
1kyvE-4jrlA:
undetectable		 1kyvA-4jrlA:
18.48
1kyvE-4jrlA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		5 / 12 ILE A 372
LEU A 371
GLY A 248
LEU A 347
ILE A 345
 None
 1.14A 1kyvB-4jrlA:
undetectable
1kyvC-4jrlA:
undetectable		 1kyvB-4jrlA:
18.48
1kyvC-4jrlA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		3 / 3 ASP A 333
LEU A 336
HIS A 322
 None
None
SO4  A 403 (-4.6A)
 0.78A 1qknA-4jrlA:
undetectable		 1qknA-4jrlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		5 / 9 THR A 363
GLY A 361
TYR A 258
THR A 196
LEU A 364
 None
 1.29A 2npnA-4jrlA:
undetectable		 2npnA-4jrlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 5 PRO A 307
ILE A 305
ARG A 304
ASP A 273
 None
 1.10A 2rhmB-4jrlA:
undetectable		 2rhmB-4jrlA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 5 PRO A 307
ILE A 305
ARG A 304
ASP A 273
 None
 1.06A 2rhmD-4jrlA:
undetectable		 2rhmD-4jrlA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 5 ILE A 274
PHE A 319
ASP A 309
GLU A 306
 None
 1.11A 3kp6A-4jrlA:
undetectable
3kp6B-4jrlA:
undetectable		 3kp6A-4jrlA:
18.71
3kp6B-4jrlA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 4 ALA A  59
VAL A  55
ASP A  38
LEU A  66
 GOL  A 407 (-3.2A)
GOL  A 407 ( 4.9A)
GOL  A 407 (-4.0A)
None
 1.17A 4e7gA-4jrlA:
undetectable		 4e7gA-4jrlA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 7 GLN A  64
THR A  89
THR A  86
THR A 102
 None
 1.13A 4mbsA-4jrlA:
undetectable		 4mbsA-4jrlA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		3 / 3 CYH A 373
LYS A 374
HIS A 242
 None
 1.14A 5js5A-4jrlA:
undetectable		 5js5A-4jrlA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 5 VAL A 192
THR A 180
ASN A 163
LEU A 215
 None
 1.31A 5m0iB-4jrlA:
undetectable		 5m0iB-4jrlA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4jrl PUTATIVE GLYCOSIDE
HYDROLASE
(Bacteroides
ovatus) 		4 / 7 ARG A 175
THR A 180
PRO A 179
PRO A 164
 None
 1.45A 6a4iB-4jrlA:
undetectable		 6a4iB-4jrlA:
21.45