SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jrm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 10 ALA D 236
VAL D 350
HIS D 304
HIS D 342
THR D 340
 None
 1.04A 1r55A-4jrmD:
undetectable		 1r55A-4jrmD:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		3 / 3 LEU D 168
HIS D 173
ILE D 160
 None
 0.72A 1s9pB-4jrmD:
undetectable		 1s9pB-4jrmD:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 6 ALA D 163
LEU D 344
ILE D 109
SER D 161
 None
 1.08A 1sbrA-4jrmD:
undetectable
1sbrB-4jrmD:
undetectable		 1sbrA-4jrmD:
19.62
1sbrB-4jrmD:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ILE D 178
LEU D 241
HIS D 173
ALA D 183
GLY D 102
 None
 1.29A 2a58A-4jrmD:
undetectable
2a58B-4jrmD:
undetectable		 2a58A-4jrmD:
16.75
2a58B-4jrmD:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ILE D 178
LEU D 241
HIS D 173
ALA D 183
GLY D 102
 None
 1.31A 2a58B-4jrmD:
undetectable
2a58C-4jrmD:
undetectable		 2a58B-4jrmD:
16.75
2a58C-4jrmD:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ILE D 178
LEU D 241
HIS D 173
ALA D 183
GLY D 102
 None
 1.29A 2a58D-4jrmD:
undetectable
2a58E-4jrmD:
undetectable		 2a58D-4jrmD:
16.75
2a58E-4jrmD:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 MET D 239
ALA D 188
VAL D   6
GLY D 189
ILE D 171
 None
 1.28A 2dcfA-4jrmD:
undetectable		 2dcfA-4jrmD:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 8 TYR D  62
GLY D 235
GLY D  78
ALA D  80
ALA D  81
 None
 1.27A 2ej3A-4jrmD:
undetectable		 2ej3A-4jrmD:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLY D  10
ALA D  85
GLY D  12
LEU D  91
LEU D  86
 None
 1.06A 2nyuB-4jrmD:
undetectable		 2nyuB-4jrmD:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		3 / 3 GLN D  32
THR D 336
TRP D  25
 None
 0.97A 2rctA-4jrmD:
undetectable		 2rctA-4jrmD:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 7 THR D 196
GLY D 199
PHE D 203
ILE D 109
 None
 0.82A 2y7wC-4jrmD:
0.7		 2y7wC-4jrmD:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 MET D 239
ALA D 188
VAL D   6
GLY D 189
ILE D 171
 None
 1.29A 3a65A-4jrmD:
undetectable		 3a65A-4jrmD:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 8 VAL D 313
GLY D 311
PRO D 273
LYS D 225
 None
 0.82A 3bjwA-4jrmD:
undetectable		 3bjwA-4jrmD:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 4 GLY D 167
GLY D 190
GLY D 106
GLY D 189
 None
 0.66A 3bogC-4jrmD:
undetectable		 3bogC-4jrmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 4 GLY D 167
GLY D 190
GLY D 106
GLY D 189
 None
 0.56A 3bogD-4jrmD:
undetectable		 3bogD-4jrmD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ILE D 238
ILE D 105
GLY D 145
LEU D  86
ARG D 151
 None
 1.18A 3em0B-4jrmD:
0.5		 3em0B-4jrmD:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		6 / 12 GLU D  22
GLY D  12
SER D 349
SER D  23
GLY D  18
SER D  24
 None
 1.20A 3g2oA-4jrmD:
undetectable		 3g2oA-4jrmD:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ILE D 171
GLY D 189
ALA D  81
ALA D 144
ALA D 346
 None
 1.07A 3jb3A-4jrmD:
undetectable		 3jb3A-4jrmD:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 11 ASP D  72
SER D 107
PHE D  57
GLU D 192
ASP D 234
 None
 1.49A 3ko0C-4jrmD:
undetectable
3ko0D-4jrmD:
undetectable
3ko0E-4jrmD:
undetectable
3ko0F-4jrmD:
undetectable		 3ko0C-4jrmD:
11.47
3ko0D-4jrmD:
11.47
3ko0E-4jrmD:
11.47
3ko0F-4jrmD:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 10 ASP D  72
SER D 107
PHE D  57
GLU D 192
ASP D 234
 None
 1.48A 3ko0O-4jrmD:
undetectable
3ko0P-4jrmD:
undetectable
3ko0Q-4jrmD:
undetectable
3ko0R-4jrmD:
undetectable		 3ko0O-4jrmD:
11.47
3ko0P-4jrmD:
11.47
3ko0Q-4jrmD:
11.47
3ko0R-4jrmD:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		3 / 3 SER D 335
GLY D 305
SER D 220
 None
 0.60A 3loqA-4jrmD:
undetectable		 3loqA-4jrmD:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_A_P77A203_1
(PROTEIN S100-A4)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 10 ASP D  72
GLU D 192
LEU D 343
ASP D 234
SER D 107
 None
 1.49A 3m0wA-4jrmD:
undetectable
3m0wB-4jrmD:
undetectable
3m0wI-4jrmD:
undetectable
3m0wJ-4jrmD:
undetectable		 3m0wA-4jrmD:
11.11
3m0wB-4jrmD:
11.11
3m0wI-4jrmD:
11.11
3m0wJ-4jrmD:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 10 ASP D  72
SER D 107
GLU D 192
LEU D 343
ASP D 234
 None
 1.46A 3m0wC-4jrmD:
undetectable
3m0wD-4jrmD:
undetectable
3m0wE-4jrmD:
undetectable
3m0wF-4jrmD:
0.0		 3m0wC-4jrmD:
11.11
3m0wD-4jrmD:
11.11
3m0wE-4jrmD:
11.11
3m0wF-4jrmD:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_D_P77D203_1
(PROTEIN S100-A4)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 10 SER D 107
GLU D 192
LEU D 343
ASP D 234
ASP D  72
 None
 1.47A 3m0wA-4jrmD:
undetectable
3m0wB-4jrmD:
undetectable
3m0wC-4jrmD:
undetectable
3m0wD-4jrmD:
undetectable		 3m0wA-4jrmD:
11.11
3m0wB-4jrmD:
11.11
3m0wC-4jrmD:
11.11
3m0wD-4jrmD:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 168
GLY D 280
GLY D 407
SER D 408
MET D 284
 None
 1.26A 3ou7A-4jrmD:
undetectable		 3ou7A-4jrmD:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 168
GLY D 280
GLY D 407
SER D 408
MET D 284
 None
 1.23A 3ou7D-4jrmD:
undetectable		 3ou7D-4jrmD:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ALA D 208
PHE D 230
ILE D 109
LEU D 344
GLY D 202
 None
 0.87A 3rukB-4jrmD:
undetectable		 3rukB-4jrmD:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 11 LEU D 147
GLY D 189
GLY D 235
ILE D  79
ILE D 143
 None
 0.72A 3s45B-4jrmD:
undetectable		 3s45B-4jrmD:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 9 ALA D 183
ARG D 100
GLY D 155
ASN D 157
ILE D 158
 None
 1.13A 3wdmA-4jrmD:
undetectable		 3wdmA-4jrmD:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 10 ALA D 183
ARG D 100
GLY D 155
ASN D 157
ILE D 158
 None
 1.16A 3wdmB-4jrmD:
undetectable		 3wdmB-4jrmD:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 7 TYR D  77
ASP D 234
SER D 195
HIS D  40
 None
 1.38A 4arcA-4jrmD:
undetectable		 4arcA-4jrmD:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 TYR D 300
SER D 358
THR D 367
ALA D 386
TRP D  25
 None
 1.41A 4dajA-4jrmD:
0.0		 4dajA-4jrmD:
23.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		10 / 12 GLY D 108
ALA D 163
CYH D 164
GLU D 192
PHE D 203
HIS D 304
THR D 306
HIS D 342
LEU D 344
GLY D 401
 None
 0.59A 4ls7A-4jrmD:
69.0		 4ls7A-4jrmD:
52.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		8 / 12 ALA D 163
CYH D 164
PHE D 203
HIS D 304
THR D 306
HIS D 342
LEU D 344
GLY D 401
 None
 0.58A 4ls7A-4jrmD:
69.0
4ls7B-4jrmD:
68.8		 4ls7A-4jrmD:
52.12
4ls7B-4jrmD:
52.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		6 / 12 ILE D 109
ALA D 163
CYH D 164
HIS D 304
HIS D 342
GLY D 401
 None
 0.80A 4ls7A-4jrmD:
69.0
4ls7B-4jrmD:
68.8		 4ls7A-4jrmD:
52.12
4ls7B-4jrmD:
52.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 232
ALA D 208
PHE D 230
ILE D 109
LEU D 344
 None
 0.95A 4nkvB-4jrmD:
undetectable		 4nkvB-4jrmD:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 232
PHE D 230
ILE D 109
LEU D 344
GLY D 202
 None
 0.95A 4nkvB-4jrmD:
undetectable		 4nkvB-4jrmD:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 232
ALA D 208
PHE D 230
ILE D 109
GLY D 202
 None
 0.96A 4nkxA-4jrmD:
undetectable		 4nkxA-4jrmD:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ASN D 170
ILE D 149
ASN D 146
GLY D 152
ASN D 157
 None
 1.23A 4obwA-4jrmD:
undetectable		 4obwA-4jrmD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LYS D 337
GLY D 345
ILE D 105
ASN D 170
GLY D  78
 None
 1.32A 4obwD-4jrmD:
undetectable		 4obwD-4jrmD:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		6 / 9 ALA D 191
VAL D 240
GLY D  12
ALA D  81
ILE D 143
VAL D 187
 None
 1.33A 4r21B-4jrmD:
undetectable		 4r21B-4jrmD:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 ALA D 236
ALA D 144
ILE D 105
GLY D  12
GLN D  84
 None
 1.17A 4r38B-4jrmD:
undetectable		 4r38B-4jrmD:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 TYR D 300
SER D 358
THR D 367
ALA D 386
TRP D  25
 None
 1.44A 4u15B-4jrmD:
undetectable		 4u15B-4jrmD:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 7 CYH D 164
GLY D 407
ASN D 406
HIS D 304
 None
 1.19A 5a5zC-4jrmD:
undetectable		 5a5zC-4jrmD:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 147
GLY D 189
GLY D 235
ILE D  79
ILE D 143
 None
 0.71A 5e5jA-4jrmD:
undetectable		 5e5jA-4jrmD:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		6 / 12 SER D 349
GLY D 348
GLY D 108
GLY D 106
GLY D 167
ILE D 109
 None
 1.38A 5ec8A-4jrmD:
undetectable		 5ec8A-4jrmD:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLY D 280
GLY D 407
SER D 408
MET D 284
GLY D 311
 None
 1.17A 5hikA-4jrmD:
undetectable		 5hikA-4jrmD:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLY D 190
GLY D 189
ALA D 352
LEU D 409
GLY D  82
 None
 0.94A 5kb5A-4jrmD:
undetectable		 5kb5A-4jrmD:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLY D 172
ILE D 178
ALA D 188
GLY D 189
ALA D 104
 None
 0.89A 5kb6A-4jrmD:
undetectable		 5kb6A-4jrmD:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLY D 172
ILE D 178
ALA D 188
GLY D 189
ALA D 104
 None
 0.86A 5kb6B-4jrmD:
undetectable		 5kb6B-4jrmD:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLU D 315
HIS D 342
SER D 335
GLY D 407
LEU D 168
 None
 1.39A 5m50B-4jrmD:
undetectable		 5m50B-4jrmD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 5 ILE D 319
PHE D 400
SER D 408
ALA D 303
 None
 1.18A 5msdA-4jrmD:
undetectable		 5msdA-4jrmD:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 9 LEU D 168
ILE D 171
GLY D 189
GLY D 190
ALA D 352
 None
 0.97A 5o96A-4jrmD:
undetectable
5o96B-4jrmD:
undetectable		 5o96A-4jrmD:
22.33
5o96B-4jrmD:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 GLY D  10
VAL D   8
PHE D 411
GLY D 167
GLY D 348
 None
 1.21A 6brdB-4jrmD:
undetectable		 6brdB-4jrmD:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		5 / 12 LEU D 147
GLY D 189
GLY D 235
ILE D  79
ILE D 143
 None
 0.79A 6dh3A-4jrmD:
undetectable		 6dh3A-4jrmD:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Vibrio
cholerae) 		4 / 8 SER D  23
GLY D 233
SER D 195
ASN D  19
 None
 0.99A 6giqL-4jrmD:
undetectable
6giqP-4jrmD:
undetectable
6giqT-4jrmD:
undetectable		 6giqL-4jrmD:
22.73
6giqP-4jrmD:
19.31
6giqT-4jrmD:
11.44