SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jrn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
5 / 10 ALA A 269
LEU A 278
MET A 356
ARG A 250
LEU A 258
None
None
ANP  A 601 (-3.3A)
None
ANP  A 601 ( 4.6A)
1.46A 1a52B-4jrnA:
undetectable
1a52B-4jrnA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
5 / 10 GLY A 487
GLN A 505
TYR A 474
TYR A 491
THR A 483
None
1.43A 1kvlA-4jrnA:
undetectable
1kvlA-4jrnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 9 LEU A 258
GLY A 259
VAL A 266
ALA A 279
ALA A 359
LEU A 416
ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.5A)
ANP  A 601 ( 4.9A)
0.86A 1muoA-4jrnA:
6.0
1muoA-4jrnA:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 9 LEU A 258
VAL A 266
ALA A 279
MET A 356
ALA A 359
LEU A 416
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 (-3.5A)
ANP  A 601 ( 4.9A)
0.89A 1xbbA-4jrnA:
21.8
1xbbA-4jrnA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 6 LEU A 389
TYR A 388
ILE A 204
ARG A 321
None
0.90A 2du8B-4jrnA:
undetectable
2du8B-4jrnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 11 GLY A 259
GLY A 261
VAL A 266
ALA A 279
MET A 356
ALA A 359
LEU A 416
ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 (-3.5A)
ANP  A 601 ( 4.9A)
0.75A 2evaA-4jrnA:
18.2
2evaA-4jrnA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 12 LEU A 258
GLY A 259
GLY A 261
VAL A 266
ALA A 279
MET A 356
LYS A 411
ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
MG  A 602 (-3.6A)
0.86A 2fumD-4jrnA:
19.6
2fumD-4jrnA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
9 / 12 LEU A 258
GLY A 259
VAL A 266
ALA A 279
LYS A 281
GLU A 300
LEU A 354
LEU A 416
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
None
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
1.02A 2ityA-4jrnA:
21.0
2ityA-4jrnA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 9 LEU A 258
VAL A 266
ALA A 279
LEU A 416
GLY A 426
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
0.60A 2xp2A-4jrnA:
19.9
2xp2A-4jrnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
5 / 11 PHE A 322
ILE A 405
PHE A 307
SER A 308
PHE A 428
None
1.13A 3a9eB-4jrnA:
undetectable
3a9eB-4jrnA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 8 ARG A 299
ASP A 465
GLN A 468
GLU A 450
None
1.13A 3dh0A-4jrnA:
undetectable
3dh0A-4jrnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 12 LEU A 258
GLY A 259
GLY A 261
VAL A 266
ALA A 279
LYS A 281
MET A 356
ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 (-3.3A)
0.54A 3fupB-4jrnA:
20.6
3fupB-4jrnA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
3 / 3 TYR A 267
LEU A 417
ARG A 358
None
0.67A 3sufB-4jrnA:
undetectable
3sufB-4jrnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 12 LEU A 258
ALA A 279
ASP A 362
LEU A 416
GLY A 426
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
0.56A 3zbfA-4jrnA:
21.1
3zbfA-4jrnA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 9 LEU A 258
VAL A 266
ALA A 279
MET A 356
LEU A 416
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
0.53A 4ansA-4jrnA:
19.8
4ansA-4jrnA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MKC_A_4MKA1503_1
(ALK TYROSINE KINASE
RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 12 LEU A 258
VAL A 266
ALA A 279
LYS A 281
ASP A 362
LEU A 416
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
0.62A 4mkcA-4jrnA:
20.3
4mkcA-4jrnA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
5 / 12 ASP A 535
VAL A 384
GLY A 197
SER A 391
SER A 390
None
1.17A 4mmdB-4jrnA:
undetectable
4mmdB-4jrnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
5 / 7 ALA A 279
ASP A 362
ASN A 414
LEU A 416
ASP A 427
ANP  A 601 ( 3.9A)
ANP  A 601 (-4.1A)
MG  A 602 (-4.3A)
ANP  A 601 ( 4.9A)
MG  A 603 ( 2.0A)
0.79A 4ogrE-4jrnA:
21.0
4ogrE-4jrnA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 6 LEU A 258
ALA A 279
MET A 356
LEU A 416
ANP  A 601 ( 4.6A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
0.69A 4wboC-4jrnA:
18.9
4wboC-4jrnA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 9 LEU A 258
VAL A 266
ALA A 279
LEU A 416
GLY A 426
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
0.68A 5aaaA-4jrnA:
20.2
5aaaA-4jrnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 10 LEU A 258
VAL A 266
ALA A 279
LYS A 281
LEU A 416
GLY A 426
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
0.89A 5aabA-4jrnA:
20.0
5aabA-4jrnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 10 LEU A 258
VAL A 266
ALA A 279
LYS A 281
LEU A 416
GLY A 426
ASP A 427
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
ANP  A 601 ( 4.9A)
None
MG  A 603 ( 2.0A)
0.89A 5aacA-4jrnA:
19.8
5aacA-4jrnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 7 GLY A 259
GLY A 261
VAL A 266
LYS A 281
ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 (-3.2A)
0.45A 5izjA-4jrnA:
19.3
5izjA-4jrnA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 7 GLY A 259
GLY A 261
VAL A 266
LYS A 281
ANP  A 601 (-3.4A)
ANP  A 601 ( 3.3A)
ANP  A 601 (-4.1A)
ANP  A 601 (-3.2A)
0.49A 5j5xA-4jrnA:
19.3
5j5xA-4jrnA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
5 / 9 GLY A 259
VAL A 266
ALA A 279
MET A 356
LEU A 416
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
1.04A 5lw1H-4jrnA:
13.7
5lw1H-4jrnA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 8 CYH A 198
TYR A 388
PHE A 424
ARG A 321
None
1.29A 5oajD-4jrnA:
undetectable
5oajE-4jrnA:
undetectable
5oajD-4jrnA:
20.16
5oajE-4jrnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
6 / 12 LEU A 258
VAL A 266
ALA A 279
LYS A 281
GLU A 300
LEU A 354
ANP  A 601 ( 4.6A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
None
0.57A 5vcyA-4jrnA:
21.3
5vcyA-4jrnA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 5 MET A 208
TYR A 388
GLY A 201
GLY A 421
None
0.99A 5x7pA-4jrnA:
undetectable
5x7pA-4jrnA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
8 / 12 LEU A 258
GLY A 259
VAL A 266
ALA A 279
LYS A 281
LEU A 354
MET A 356
LEU A 416
ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
0.92A 5yu9A-4jrnA:
18.7
5yu9A-4jrnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
7 / 12 GLY A 259
VAL A 266
ALA A 279
LYS A 281
LEU A 354
MET A 356
LEU A 416
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
0.96A 5yu9B-4jrnA:
18.8
5yu9B-4jrnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii)
4 / 5 GLN A 401
VAL A 406
PRO A 522
THR A 430
None
1.49A 6cduI-4jrnA:
undetectable
6cduJ-4jrnA:
undetectable
6cduI-4jrnA:
19.42
6cduJ-4jrnA:
19.42