SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4js1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 8 ALA A 190
GLU A 342
ASP A 339
ILE A 328
 CTN  A 510 (-3.3A)
None
None
None
 0.78A 1rg9B-4js1A:
undetectable		 1rg9B-4js1A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 4 GLN A 317
GLU A 314
ILE A 316
PRO A 371
 None
 1.28A 2fcnA-4js1A:
undetectable		 2fcnA-4js1A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 8 VAL A 256
ILE A 295
ILE A 266
PHE A 278
 None
 0.87A 3uqbA-4js1A:
undetectable		 3uqbA-4js1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		3 / 3 LEU A 209
MET A 331
ASP A 258
 None
 0.79A 4j7xB-4js1A:
undetectable		 4j7xB-4js1A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 8 ALA A 190
GLU A 342
ASP A 339
ILE A 328
 CTN  A 510 (-3.3A)
None
None
None
 0.77A 4kttB-4js1A:
undetectable		 4kttB-4js1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 8 ALA A 190
GLU A 342
ASP A 339
ILE A 328
 CTN  A 510 (-3.3A)
None
None
None
 0.82A 4kttD-4js1A:
undetectable		 4kttD-4js1A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 7 GLU A 251
ARG A 210
GLY A 224
ALA A 217
 None
 0.94A 5e26A-4js1A:
undetectable
5e26B-4js1A:
undetectable		 5e26A-4js1A:
21.29
5e26B-4js1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		3 / 3 SER A 151
LEU A 209
MET A 331
 None
 0.72A 5ikrB-4js1A:
undetectable		 5ikrB-4js1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 7 ALA A 190
GLU A 342
ASP A 339
ILE A 328
 CTN  A 510 (-3.3A)
None
None
None
 0.80A 6fbnA-4js1A:
undetectable		 6fbnA-4js1A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 4js1 BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE 1
(Homo
sapiens) 		4 / 5 SER A 260
VAL A 261
ASN A 272
PRO A 267
 None
 1.33A 6fi4A-4js1A:
undetectable
6fi4B-4js1A:
undetectable		 6fi4A-4js1A:
21.92
6fi4B-4js1A:
2.00