SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4js5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 8 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.39A 1v7zA-4js5A:
undetectable		 1v7zA-4js5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 8 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.39A 1v7zB-4js5A:
undetectable		 1v7zB-4js5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 8 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.38A 1v7zC-4js5A:
undetectable		 1v7zC-4js5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 8 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.39A 1v7zF-4js5A:
undetectable		 1v7zF-4js5A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 8 ASP A  55
PHE A  19
ASP A  26
TYR A  57
 None
 0.94A 2aouA-4js5A:
undetectable		 2aouA-4js5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 6 ARG A  87
GLU A  81
PRO A  28
ALA A  29
 None
 1.14A 2ejfB-4js5A:
undetectable		 2ejfB-4js5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 ARG A  87
GLU A  81
PRO A  28
ALA A  29
 None
 1.08A 2ejgA-4js5A:
2.1		 2ejgA-4js5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 9 TYR A 284
VAL A 298
VAL A 348
ILE A 350
VAL A 347
 None
 1.22A 2l8mA-4js5A:
undetectable		 2l8mA-4js5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 8 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.39A 3a6jA-4js5A:
undetectable		 3a6jA-4js5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 7 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.37A 3a6jB-4js5A:
undetectable		 3a6jB-4js5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 8 GLU A 167
ASP A 186
HIS A 177
HIS A 181
GLU A  17
 None
 1.37A 3a6jF-4js5A:
undetectable		 3a6jF-4js5A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		3 / 3 LEU A  91
VAL A  42
ARG A  35
 None
 0.79A 3b0wB-4js5A:
undetectable		 3b0wB-4js5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 12 PHE A 236
LEU A 309
PHE A 164
ALA A 312
ALA A 320
 None
 1.10A 3nxuB-4js5A:
undetectable		 3nxuB-4js5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 12 PHE A 236
MET A 261
LEU A 309
PHE A 164
ALA A 312
 None
 0.89A 3nxuB-4js5A:
undetectable		 3nxuB-4js5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 12 GLY A 101
ASP A 108
ILE A  34
THR A  97
ILE A  99
 None
 1.07A 4njvA-4js5A:
undetectable		 4njvA-4js5A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 GLU A 254
ILE A 350
ARG A 344
ILE A 260
 None
 0.86A 4xumA-4js5A:
undetectable		 4xumA-4js5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 ILE A 350
ARG A 344
LEU A 337
ILE A 260
 None
 0.98A 4xumA-4js5A:
undetectable		 4xumA-4js5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 LEU A 467
PRO A  59
LEU A 447
GLU A 446
 None
 0.99A 4z4fA-4js5A:
undetectable		 4z4fA-4js5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 7 THR A 314
ARG A 322
LEU A 323
VAL A 232
THR A 243
 None
 1.25A 5e4dA-4js5A:
undetectable
5e4dB-4js5A:
undetectable		 5e4dA-4js5A:
17.87
5e4dB-4js5A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		3 / 3 LEU A 450
LEU A 447
TRP A 468
 None
 0.93A 5nwuA-4js5A:
undetectable		 5nwuA-4js5A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 12 PHE A 236
LEU A 309
PHE A 164
ALA A 312
ALA A 320
 None
 1.08A 5vc0A-4js5A:
undetectable		 5vc0A-4js5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 THR A 190
VAL A 187
HIS A  14
ILE A  99
 None
 1.17A 5vkqA-4js5A:
0.8
5vkqB-4js5A:
0.0		 5vkqA-4js5A:
14.71
5vkqB-4js5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 8 THR A 190
VAL A 187
HIS A  14
ILE A  99
 None
 1.14A 5vkqB-4js5A:
0.0
5vkqC-4js5A:
undetectable		 5vkqB-4js5A:
14.71
5vkqC-4js5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 THR A 190
VAL A 187
HIS A  14
ILE A  99
 None
 1.16A 5vkqC-4js5A:
undetectable
5vkqD-4js5A:
0.0		 5vkqC-4js5A:
14.71
5vkqD-4js5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 6 PHE A 415
PRO A 416
GLY A 417
THR A 418
 None
 0.48A 5x24A-4js5A:
undetectable		 5x24A-4js5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		5 / 12 ASN A 119
LEU A 419
THR A 418
LEU A 391
PHE A 415
 None
 1.17A 5xxiA-4js5A:
undetectable		 5xxiA-4js5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 7 LEU A 384
ALA A  85
ALA A  86
THR A  93
 None
 0.75A 6a7jA-4js5A:
undetectable		 6a7jA-4js5A:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4js5 EXODEOXYRIBONUCLEASE
I
(Escherichia
coli) 		4 / 8 ASP A 108
HIS A  14
GLU A  17
GLU A 167
 None
 1.04A 6mn4C-4js5A:
undetectable		 6mn4C-4js5A:
21.38