SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		4 / 7 MET A  43
SER A  72
ALA A 136
ALA A  38
 None
 1.06A 1k5qA-4jsbA:
undetectable
1k5qB-4jsbA:
undetectable		 1k5qA-4jsbA:
20.13
1k5qB-4jsbA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		4 / 8 ILE A 126
SER A 125
ASP A 145
LEU A 220
 None
 0.99A 2cdqA-4jsbA:
undetectable		 2cdqA-4jsbA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		5 / 12 LEU A  12
LEU A  17
LEU A  30
VAL A 129
VAL A  61
 None
 1.07A 2pnjA-4jsbA:
undetectable		 2pnjA-4jsbA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		5 / 9 ALA A 133
ALA A 141
SER A 143
PHE A 115
ALA A 136
 None
 1.24A 2vh3A-4jsbA:
undetectable		 2vh3A-4jsbA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		3 / 3 ARG A  42
GLY A  41
SER A  71
 None
 0.42A 2xctB-4jsbA:
undetectable		 2xctB-4jsbA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		5 / 12 LEU A 168
SER A 110
ASP A  75
ASP A  77
MET A  78
 None
 1.02A 4j7xJ-4jsbA:
undetectable		 4j7xJ-4jsbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		4 / 6 PHE A 138
SER A  71
ALA A 133
LEU A 140
 None
 1.26A 5dzkB-4jsbA:
11.5
5dzkP-4jsbA:
undetectable		 5dzkB-4jsbA:
23.18
5dzkP-4jsbA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4jsb ENOYL-COA HYDRATASE
(Thermobifida
fusca) 		4 / 6 PHE A 138
SER A  71
ALA A 133
LEU A 140
 None
 1.30A 5dzkg-4jsbA:
11.5
5dzku-4jsbA:
undetectable		 5dzkg-4jsbA:
23.18
5dzku-4jsbA:
1.74