SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jso'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ALA A  13
LEU A 232
SER A 219
PHE A 222
ILE A  10
 None
BGC  A 601 (-3.8A)
None
None
None
 1.22A 1g5yC-4jsoA:
undetectable		 1g5yC-4jsoA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A 412
VAL A 376
TRP A 380
 None
None
BGC  A 601 (-4.0A)
 0.87A 1jnoA-4jsoA:
undetectable		 1jnoA-4jsoA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A 412
VAL A 376
TRP A 380
 None
None
BGC  A 601 (-4.0A)
 0.87A 1jnoB-4jsoA:
undetectable		 1jnoB-4jsoA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 337
ASN A 291
ASP A 334
GLY A 335
PHE A 330
 None
 1.32A 1jujA-4jsoA:
undetectable		 1jujA-4jsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 337
ASN A 291
ASP A 334
GLY A 335
PHE A 330
 None
 1.32A 1jujB-4jsoA:
undetectable		 1jujB-4jsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 337
ASN A 291
ASP A 334
GLY A 335
PHE A 330
 None
 1.32A 1jujC-4jsoA:
undetectable		 1jujC-4jsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 337
ASN A 291
ASP A 334
GLY A 335
PHE A 330
 None
 1.32A 1jujD-4jsoA:
undetectable		 1jujD-4jsoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A 412
VAL A 376
TRP A 380
 None
None
BGC  A 601 (-4.0A)
 0.85A 1ng8A-4jsoA:
undetectable		 1ng8A-4jsoA:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ALA A 412
VAL A 376
TRP A 380
 None
None
BGC  A 601 (-4.0A)
 0.85A 1ng8B-4jsoA:
undetectable		 1ng8B-4jsoA:
2.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 411
PHE A 408
TRP A 380
 None
BGC  A 603 (-4.6A)
BGC  A 601 (-4.0A)
 1.47A 1r15C-4jsoA:
undetectable		 1r15C-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 411
PHE A 408
TRP A 380
 None
BGC  A 603 (-4.6A)
BGC  A 601 (-4.0A)
 1.44A 1r15F-4jsoA:
undetectable		 1r15F-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 411
PHE A 408
TRP A 380
 None
BGC  A 603 (-4.6A)
BGC  A 601 (-4.0A)
 1.45A 1r15G-4jsoA:
undetectable		 1r15G-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 411
PHE A 408
TRP A 380
 None
BGC  A 603 (-4.6A)
BGC  A 601 (-4.0A)
 1.45A 1r15H-4jsoA:
undetectable		 1r15H-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 THR A 419
ASP A 421
THR A 373
ASP A 400
 None
 1.05A 2okcB-4jsoA:
undetectable		 2okcB-4jsoA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 298
ALA A 504
ALA A 305
LEU A 313
 None
 0.93A 2wx2A-4jsoA:
undetectable		 2wx2A-4jsoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 298
ALA A 504
ALA A 305
LEU A 313
 None
 1.01A 2wx2B-4jsoA:
undetectable		 2wx2B-4jsoA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 193
VAL A 170
TRP A 194
 None
 1.34A 2xdcE-4jsoA:
undetectable
2xdcF-4jsoA:
undetectable		 2xdcE-4jsoA:
2.43
2xdcF-4jsoA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 265
TYR A 496
ILE A 284
LEU A 443
TYR A 439
 None
 1.40A 2xkwA-4jsoA:
undetectable		 2xkwA-4jsoA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ILE A 311
PRO A 435
VAL A  53
PHE A 432
 None
 1.23A 2ygnA-4jsoA:
undetectable		 2ygnA-4jsoA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 0.95A 3abkC-4jsoA:
0.5		 3abkC-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 5 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 0.98A 3ablC-4jsoA:
undetectable
3ablJ-4jsoA:
undetectable		 3ablC-4jsoA:
18.63
3ablJ-4jsoA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 1.00A 3ablP-4jsoA:
undetectable
3ablW-4jsoA:
undetectable		 3ablP-4jsoA:
18.63
3ablW-4jsoA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 GLY A 302
ALA A 508
LEU A 313
PRO A 260
 None
 0.95A 3bgdA-4jsoA:
undetectable		 3bgdA-4jsoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 PHE A 258
GLY A 302
LEU A 313
PRO A 260
 None
 1.11A 3bgdB-4jsoA:
undetectable		 3bgdB-4jsoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 GLU A 461
SER A 427
VAL A 428
 None
 0.80A 3eeoA-4jsoA:
undetectable		 3eeoA-4jsoA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 298
ALA A 504
ALA A 305
LEU A 313
 None
 0.87A 3khmA-4jsoA:
undetectable		 3khmA-4jsoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 178
PRO A 166
GLN A 169
GLU A 167
 None
 1.20A 3l2vA-4jsoA:
undetectable		 3l2vA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 179
PRO A 166
GLN A 169
GLU A 167
 None
 1.17A 3l2vA-4jsoA:
undetectable		 3l2vA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 298
ALA A 504
ALA A 305
LEU A 313
 None
 0.95A 3l4dA-4jsoA:
undetectable		 3l4dA-4jsoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 298
ALA A 504
ALA A 305
LEU A 313
 None
 0.99A 3l4dD-4jsoA:
undetectable		 3l4dD-4jsoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 495
ILE A 491
ILE A 438
SER A 427
SER A 501
 None
 1.20A 3o1cA-4jsoA:
undetectable		 3o1cA-4jsoA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 495
ILE A 491
ILE A 438
SER A 427
SER A 501
 None
 1.08A 3o1xA-4jsoA:
undetectable		 3o1xA-4jsoA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 TYR A 179
PRO A 166
GLN A 169
GLU A 167
 None
 1.12A 3oyaA-4jsoA:
undetectable		 3oyaA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 10 ILE A 495
ILE A 491
ILE A 438
SER A 427
SER A 501
 None
 1.10A 3qgzA-4jsoA:
undetectable		 3qgzA-4jsoA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 178
PRO A 166
GLN A 169
GLU A 167
 None
 1.09A 3s3oA-4jsoA:
undetectable		 3s3oA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 179
PRO A 166
GLN A 169
GLU A 167
 None
 1.21A 3s3oA-4jsoA:
undetectable		 3s3oA-4jsoA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 TYR A 187
ASN A 163
GLN A  34
TYR A 149
 None
None
BGC  A 604 (-2.8A)
None
 1.29A 3ugrA-4jsoA:
undetectable		 3ugrA-4jsoA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 LYS A 165
GLU A 168
TRP A 161
 None
 1.47A 3v4tH-4jsoA:
2.0		 3v4tH-4jsoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 193
VAL A 170
TRP A 194
 None
 1.03A 3zq8A-4jsoA:
undetectable
3zq8B-4jsoA:
undetectable		 3zq8A-4jsoA:
2.43
3zq8B-4jsoA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 PHE A 134
LEU A 139
ILE A 574
TYR A  58
ALA A 581
 None
 1.39A 4a83A-4jsoA:
undetectable		 4a83A-4jsoA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 PHE A 265
VAL A 263
ILE A 311
GLU A 461
 None
 1.07A 4a97E-4jsoA:
undetectable		 4a97E-4jsoA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 540
TRP A 529
THR A 542
 None
 1.35A 4bboB-4jsoA:
undetectable		 4bboB-4jsoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ASP A 538
HIS A 509
ASP A 261
HIS A 536
GLY A 262
 None
None
BGC  A 602 ( 4.9A)
None
None
 1.40A 4bz6A-4jsoA:
undetectable
4bz6B-4jsoA:
undetectable		 4bz6A-4jsoA:
21.31
4bz6B-4jsoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ASP A 538
PHE A 530
ASP A 261
HIS A 536
GLY A 262
 None
None
BGC  A 602 ( 4.9A)
None
None
 1.30A 4bz6A-4jsoA:
undetectable
4bz6B-4jsoA:
undetectable		 4bz6A-4jsoA:
21.31
4bz6B-4jsoA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 TYR A 506
HIS A 306
ARG A 336
 None
 1.11A 4htfA-4jsoA:
undetectable		 4htfA-4jsoA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 ASN A 270
ASP A 466
ASP A 498
ILE A 494
 None
 0.92A 4k0bA-4jsoA:
undetectable		 4k0bA-4jsoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 8 ASN A 270
ASP A 466
ASP A 498
ILE A 494
 None
 0.91A 4l7iA-4jsoA:
undetectable		 4l7iA-4jsoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 GLU A 576
TYR A  58
LEU A 139
PHE A  60
 None
 1.22A 4twdF-4jsoA:
undetectable
4twdJ-4jsoA:
undetectable		 4twdF-4jsoA:
18.15
4twdJ-4jsoA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 GLY A 102
GLY A 104
LEU A  23
ASP A  33
ALA A  90
 None
None
BGC  A 605 (-4.6A)
CA  A 606 ( 3.4A)
None
 1.10A 4uckB-4jsoA:
undetectable		 4uckB-4jsoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A 459
ARG A 281
PRO A 500
 None
 0.81A 4wanC-4jsoA:
undetectable		 4wanC-4jsoA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 0.93A 5b1bC-4jsoA:
undetectable
5b1bJ-4jsoA:
undetectable		 5b1bC-4jsoA:
18.63
5b1bJ-4jsoA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 ASP A  33
PRO A 174
TYR A 187
LEU A 207
 CA  A 606 ( 3.4A)
None
None
None
 1.24A 5bmvB-4jsoA:
undetectable		 5bmvB-4jsoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 6 GLU A 388
GLY A 359
ASP A 358
GLY A 398
 None
 0.74A 5cdpA-4jsoA:
3.0
5cdpB-4jsoA:
undetectable		 5cdpA-4jsoA:
22.67
5cdpB-4jsoA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A  38
ASP A 191
LEU A 201
PRO A 556
VAL A 171
 None
 1.04A 5dlvB-4jsoA:
undetectable		 5dlvB-4jsoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ALA A 141
LEU A 139
SER A 136
ALA A  40
ALA A  90
 None
 1.32A 5jglA-4jsoA:
undetectable		 5jglA-4jsoA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 TYR A 108
ILE A 109
PHE A 436
GLY A 102
LEU A 447
 None
 1.23A 5v5zA-4jsoA:
undetectable		 5v5zA-4jsoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		5 / 12 ASP A 473
PHE A 134
PHE A 436
ILE A  68
ALA A  40
 None
 1.12A 5vc0A-4jsoA:
undetectable		 5vc0A-4jsoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		3 / 3 ARG A 484
PHE A 134
LEU A 479
 None
 0.78A 5x1bC-4jsoA:
undetectable		 5x1bC-4jsoA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 VAL A 115
PRO A  39
LEU A  38
PHE A 122
 None
 1.02A 6aycA-4jsoA:
0.6		 6aycA-4jsoA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 7 SER A 308
ALA A 305
ILE A 288
ALA A 285
 None
 0.93A 6ma7A-4jsoA:
undetectable		 6ma7A-4jsoA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4jso OLIGOPEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN
(Thermotoga
maritima) 		4 / 4 ARG A 484
GLN A 133
PHE A 134
LEU A 479
 None
 1.13A 6nmfC-4jsoA:
0.7		 6nmfC-4jsoA:
18.63