SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jtv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 SER A 127
TRP A 129
ASP A 244
ILE A 246
 None
 1.34A 2oxtD-4jtvA:
undetectable		 2oxtD-4jtvA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 ASP A  41
ASN A 300
THR A 305
 None
 0.74A 2pymB-4jtvA:
undetectable		 2pymB-4jtvA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 LYS A 148
LYS A 136
VAL A 138
 SIA  A 605 (-3.3A)
None
None
 0.70A 3brfA-4jtvA:
undetectable		 3brfA-4jtvA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		5 / 11 ASN A 326
THR A  31
ALA A 321
SER A  35
HIS A  34
 None
 1.40A 3kp5A-4jtvA:
undetectable		 3kp5A-4jtvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 ASN A 326
THR A  31
ALA A 321
SER A  35
HIS A  34
 None
 1.37A 4ejwA-4jtvA:
undetectable		 4ejwA-4jtvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 LEU A 180
TYR A 151
PRO A 257
ILE A 122
 None
 1.32A 5esgA-4jtvA:
undetectable		 5esgA-4jtvA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4jtv HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 GLY A  69
ASN A 153
SER A  77
ARG A 119
 None
 1.06A 6dwdA-4jtvA:
undetectable
6dwdC-4jtvA:
undetectable		 6dwdA-4jtvA:
21.74
6dwdC-4jtvA:
21.74