SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4juo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 5 ARG C 601
ALA C 538
LYS C 500
GLU C 428
 None
 1.14A 1e7cA-4juoC:
undetectable		 1e7cA-4juoC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		5 / 11 LEU C 328
GLY C 284
GLU C 287
GLY C 283
PRO C 333
 None
 1.13A 1p91A-4juoC:
undetectable		 1p91A-4juoC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		5 / 12 VAL C 126
LEU C 130
LEU C 102
PHE C 183
GLY C  34
 None
 1.17A 3kk6B-4juoC:
undetectable		 3kk6B-4juoC:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 8 TYR C 580
THR C 595
TYR C 557
TRP C 559
 None
 1.42A 3wipB-4juoC:
undetectable
3wipC-4juoC:
undetectable		 3wipB-4juoC:
15.19
3wipC-4juoC:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 8 TYR C 580
THR C 595
TYR C 557
TRP C 559
 None
 1.40A 3wipC-4juoC:
undetectable
3wipD-4juoC:
undetectable		 3wipC-4juoC:
15.19
3wipD-4juoC:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 8 TRP C 559
TYR C 580
THR C 595
TYR C 557
 None
 1.43A 3wipA-4juoC:
undetectable
3wipE-4juoC:
undetectable		 3wipA-4juoC:
15.19
3wipE-4juoC:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		4 / 5 HIS C 534
ILE C 502
ILE C 501
TYR C 430
 None
 1.26A 5dnuA-4juoC:
3.6		 5dnuA-4juoC:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4juo DNA TOPOISOMERASE 4
SUBUNIT B
(Streptococcus
pneumoniae) 		5 / 9 GLN C 450
LEU C 603
ALA C 441
VAL C 432
ALA C 538
 None
 1.20A 5g44A-4juoC:
undetectable		 5g44A-4juoC:
18.59