SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		4 / 8 LEU A  33
ASN A  71
LEU A  76
LEU A  77
 None
 0.97A 1e7cA-4jupA:
undetectable		 1e7cA-4jupA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		4 / 8 PHE A  91
SER A  34
ILE A  37
LEU A  77
 None
 0.76A 1eupA-4jupA:
undetectable		 1eupA-4jupA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		4 / 7 VAL A  90
VAL A  26
TYR A  36
CYH A  49
 None
 1.05A 1t46A-4jupA:
undetectable		 1t46A-4jupA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		5 / 12 VAL A 106
LEU A  80
LEU A  33
SER A  94
LEU A  95
 None
 0.99A 3n8wA-4jupA:
undetectable		 3n8wA-4jupA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		5 / 12 VAL A 106
LEU A  80
LEU A  33
SER A  94
LEU A  95
 None
 1.00A 3n8zA-4jupA:
undetectable		 3n8zA-4jupA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		4 / 8 PHE A  91
GLY A  87
TYR A  98
PHE A  97
 None
 0.98A 5flcB-4jupA:
undetectable		 5flcB-4jupA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		4 / 8 PHE A  91
GLY A  87
TYR A  98
PHE A  97
 None
 0.98A 5flcF-4jupA:
undetectable		 5flcF-4jupA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 4jup CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 11
(Homo
sapiens) 		5 / 12 VAL A  26
GLU A  27
LEU A  46
THR A  43
GLY A  74
 None
 0.79A 6b0cD-4jupA:
undetectable		 6b0cD-4jupA:
20.79