SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		3 / 3 LEU A 576
SER A 542
ASN A 569
 ACY  A 701 ( 4.5A)
None
None
 0.80A 1bx4A-4jvsA:
undetectable		 1bx4A-4jvsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		5 / 12 ALA A 421
LEU A 560
ILE A 547
LEU A 576
TYR A 451
 None
None
ACY  A 701 (-4.4A)
ACY  A 701 ( 4.5A)
None
 1.00A 1ddrB-4jvsA:
undetectable		 1ddrB-4jvsA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		4 / 8 GLY B  86
HIS B  85
ALA B 113
ILE B  87
 None
 0.78A 1gtnE-4jvsB:
undetectable
1gtnF-4jvsB:
undetectable		 1gtnE-4jvsB:
16.86
1gtnF-4jvsB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		3 / 3 ASP B  66
LEU B  29
LEU B  28
 MG  B 402 ( 3.8A)
None
None
 0.72A 1ikeA-4jvsB:
undetectable		 1ikeA-4jvsB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Legionella
drancourtii;
Homo
sapiens) 		4 / 8 ILE B  76
VAL A 438
MET A 445
SER B  42
 None
None
None
AF3  B 401 (-2.0A)
 1.10A 1kb9A-4jvsB:
undetectable
1kb9C-4jvsB:
undetectable
1kb9D-4jvsB:
undetectable
1kb9E-4jvsB:
undetectable		 1kb9A-4jvsB:
18.41
1kb9C-4jvsB:
17.16
1kb9D-4jvsB:
19.92
1kb9E-4jvsB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		5 / 12 ILE B  60
THR B 153
VAL B 161
LEU B  16
ILE B  64
 None
 1.08A 1kqwA-4jvsB:
undetectable		 1kqwA-4jvsB:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		4 / 5 TRP A 351
VAL A 368
THR A 365
ILE A 480
 None
 1.38A 1ss4A-4jvsA:
undetectable		 1ss4A-4jvsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		5 / 10 LEU A 594
ALA A 561
ILE A 580
LEU A 560
LEU A 581
 None
 1.12A 1yi4A-4jvsA:
undetectable		 1yi4A-4jvsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		5 / 12 THR B  43
GLY B  23
GLY B  21
GLY B  69
ASP B 127
 MG  B 402 (-2.8A)
GDP  B 400 (-3.0A)
GDP  B 400 ( 3.5A)
AF3  B 401 (-3.7A)
GDP  B 400 (-2.8A)
 1.02A 2b25A-4jvsB:
undetectable		 2b25A-4jvsB:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		4 / 5 ARG A 602
PHE A 599
THR A 562
LEU A 560
 None
 1.28A 2e1qD-4jvsA:
undetectable		 2e1qD-4jvsA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Legionella
drancourtii;
Homo
sapiens) 		4 / 4 SER A 593
GLY A 557
HIS A 418
ASP B  95
 None
None
GDP  B 400 ( 4.8A)
None
 1.07A 2oxtC-4jvsA:
undetectable		 2oxtC-4jvsA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		5 / 12 ILE B 148
TYR B  91
VAL B  93
LEU B 121
LEU B  27
 None
 1.00A 2rctA-4jvsB:
undetectable		 2rctA-4jvsB:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		4 / 8 SER B  78
VAL B  46
TYR B 112
ASN A 479
 None
 1.14A 2wekA-4jvsB:
undetectable		 2wekA-4jvsB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		4 / 8 SER B  78
VAL B  46
TYR B 112
ASN A 479
 None
 1.16A 2wekB-4jvsB:
undetectable		 2wekB-4jvsB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		4 / 6 ASP A 495
ILE A 487
GLN A 483
TYR B  80
 None
 1.37A 2ya7C-4jvsA:
undetectable		 2ya7C-4jvsA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		5 / 12 GLY A 353
ALA A 508
ILE A 480
LEU A 484
VAL A 363
 None
 1.10A 3adsB-4jvsA:
undetectable		 3adsB-4jvsA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		5 / 10 ALA A 421
ILE A 547
LEU A 576
PHE A 544
TYR A 451
 None
ACY  A 701 (-4.4A)
ACY  A 701 ( 4.5A)
None
None
 1.14A 3fl9A-4jvsA:
undetectable		 3fl9A-4jvsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		5 / 9 GLY B  69
GLY B  23
ILE B  41
MET A 445
PHE A 448
 AF3  B 401 (-3.7A)
GDP  B 400 (-3.0A)
None
None
None
 1.40A 3ko0F-4jvsB:
undetectable
3ko0G-4jvsB:
undetectable		 3ko0F-4jvsB:
20.99
3ko0G-4jvsB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens;
Legionella
drancourtii) 		5 / 10 GLY B  23
ILE B  41
MET A 445
PHE A 448
GLY B  69
 GDP  B 400 (-3.0A)
None
None
None
AF3  B 401 (-3.7A)
 1.34A 3ko0R-4jvsB:
undetectable
3ko0T-4jvsB:
undetectable		 3ko0R-4jvsB:
20.99
3ko0T-4jvsB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
RAS-RELATED PROTEIN
RAB-1A
(Legionella
drancourtii;
Homo
sapiens) 		5 / 9 ILE B  76
GLY B  45
PHE B  73
THR A 475
ARG A 460
 None
 1.32A 4acaB-4jvsB:
15.9
4acaC-4jvsB:
15.4		 4acaB-4jvsB:
18.50
4acaC-4jvsB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		3 / 3 TYR B  81
ARG B  74
SER B  78
 None
 1.18A 4dr2I-4jvsB:
undetectable
4dr2J-4jvsB:
undetectable		 4dr2I-4jvsB:
23.33
4dr2J-4jvsB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		5 / 12 ILE B 148
TYR B  91
VAL B  93
LEU B 121
LEU B  27
 None
 0.97A 4qzuC-4jvsB:
undetectable		 4qzuC-4jvsB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens) 		3 / 3 LYS B  24
GLN B 104
ASN B 101
 GDP  B 400 ( 2.6A)
None
None
 0.68A 5l2tA-4jvsB:
undetectable		 5l2tA-4jvsB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 4jvs PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
drancourtii) 		5 / 12 LEU A 335
LEU A 354
ILE A 480
LEU A 505
LEU A 347
 None
 1.27A 5toaB-4jvsA:
undetectable		 5toaB-4jvsA:
22.43