SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		3 / 3 ALA A 463
VAL A 465
TRP A 464
 None
 0.93A 1bdwA-4jw1A:
undetectable
1bdwB-4jw1A:
undetectable		 1bdwA-4jw1A:
2.33
1bdwB-4jw1A:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 11 PHE A 144
LEU A 148
LEU A 301
LEU A 241
LEU A 237
 None
 0.97A 1dtlA-4jw1A:
undetectable		 1dtlA-4jw1A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 9 VAL A 153
LEU A 214
ALA A 141
SER A 145
LEU A 142
 None
 1.17A 1eqgA-4jw1A:
undetectable		 1eqgA-4jw1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 11 VAL A 153
LEU A 214
ALA A 141
SER A 145
LEU A 142
 None
 1.16A 1eqgB-4jw1A:
undetectable		 1eqgB-4jw1A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 7 GLN A 171
MET A 143
MET A 140
ALA A 141
 None
 1.20A 1linA-4jw1A:
undetectable		 1linA-4jw1A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 LEU A 147
GLU A 298
LEU A 242
LEU A  65
 None
 0.79A 1mt1D-4jw1A:
undetectable
1mt1E-4jw1A:
undetectable		 1mt1D-4jw1A:
11.67
1mt1E-4jw1A:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 THR A 472
LEU A 471
VAL A 435
PHE A 510
LEU A 381
 None
 1.14A 1wsvA-4jw1A:
undetectable		 1wsvA-4jw1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 PHE A  71
ARG A  63
GLY A  64
LYS A  62
 None
 1.22A 2i30A-4jw1A:
undetectable		 2i30A-4jw1A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 LEU A  56
LEU A  57
GLY A  54
GLN A 171
MET A 293
 None
 1.27A 2q7lA-4jw1A:
undetectable		 2q7lA-4jw1A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 HIS A 151
ASP A 179
ARG A 300
HIS A 186
 None
 1.38A 2r6vA-4jw1A:
0.0		 2r6vA-4jw1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 ILE A 584
ALA A 587
GLU A 561
ASN A 563
LEU A 562
 None
 1.39A 3eigA-4jw1A:
undetectable		 3eigA-4jw1A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 ILE A 304
ARG A 300
LEU A 297
LEU A 148
 None
 0.84A 3kp6A-4jw1A:
1.3
3kp6B-4jw1A:
undetectable		 3kp6A-4jw1A:
15.09
3kp6B-4jw1A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 9 ILE A 517
ILE A 467
ALA A 382
LEU A 381
ALA A 513
 None
 0.89A 3ozvB-4jw1A:
3.2		 3ozvB-4jw1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 PHE A  52
PHE A 280
PHE A 289
ALA A 290
 None
 1.18A 3t3sB-4jw1A:
undetectable		 3t3sB-4jw1A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		3 / 3 LYS A 168
VAL A 153
HIS A 154
 None
 1.16A 3tj7A-4jw1A:
undetectable		 3tj7A-4jw1A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		3 / 3 LYS A 327
PRO A 328
LEU A 329
 None
 0.81A 3tpxE-4jw1A:
undetectable		 3tpxE-4jw1A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		3 / 3 PHE A 172
LYS A 168
SER A 169
 None
 1.00A 3tyeB-4jw1A:
undetectable		 3tyeB-4jw1A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 CYH A 385
THR A 384
ASN A 388
ILE A 517
 None
 1.42A 3w9tB-4jw1A:
undetectable		 3w9tB-4jw1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 6 THR A 434
ASN A 375
ASP A 379
ILE A 383
 None
 1.37A 3w9tB-4jw1A:
undetectable		 3w9tB-4jw1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 7 HIS A 151
ASP A 179
ARG A 300
HIS A 186
 None
 1.43A 3zodA-4jw1A:
undetectable		 3zodA-4jw1A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 11 ILE A 245
ALA A 249
LEU A  57
PHE A  60
LEU A 147
 None
 1.34A 4i1nA-4jw1A:
undetectable		 4i1nA-4jw1A:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 10 VAL A 153
LEU A 214
ALA A 141
SER A 145
LEU A 142
 None
 1.12A 4ph9A-4jw1A:
undetectable		 4ph9A-4jw1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 GLN A  81
ASP A 256
LEU A 257
GLU A  83
GLY A  88
 None
 1.29A 4retA-4jw1A:
3.0		 4retA-4jw1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 GLN A  81
ASP A 256
LEU A 257
GLU A  83
GLY A  88
 None
 1.29A 4retC-4jw1A:
undetectable		 4retC-4jw1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 GLN A  81
ASP A 256
LEU A 257
GLU A  83
GLY A  88
 None
 1.26A 4xe5A-4jw1A:
2.9		 4xe5A-4jw1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 5 ASP A 361
VAL A 496
ASP A 493
GLY A 491
 None
 1.24A 4xp6A-4jw1A:
undetectable		 4xp6A-4jw1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 7 GLN A 373
LEU A 376
ASP A 379
ALA A 382
 None
 1.02A 5nwvA-4jw1A:
undetectable		 5nwvA-4jw1A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		4 / 8 ILE A 467
TRP A 464
TYR A 455
VAL A 390
 None
 1.05A 5vlmF-4jw1A:
2.3		 5vlmF-4jw1A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 4jw1 EFFECTOR PROTEIN B
(Legionella
pneumophila) 		5 / 12 LEU A  55
GLY A  54
LEU A  93
VAL A  94
ILE A  75
 None
 0.90A 6bxmA-4jw1A:
undetectable		 6bxmA-4jw1A:
19.72