SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4jwc CHAPERONE PROTEIN
DNAK
(Escherichia
coli) 		4 / 5 THR A 410
LEU A 441
GLY A 443
LYS A 446
 None
 1.35A 1gtiF-4jwcA:
undetectable		 1gtiF-4jwcA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4jwc CHAPERONE PROTEIN
DNAK
(Escherichia
coli) 		4 / 8 GLY A 461
ILE A 462
ASN A 492
SER A 493
 None
 0.88A 2a8tB-4jwcA:
undetectable		 2a8tB-4jwcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 4jwc CHAPERONE PROTEIN
DNAK
(Escherichia
coli) 		4 / 4 GLN A 442
GLU A 511
ILE A 512
PRO A 396
 None
 1.37A 2fcnA-4jwcA:
undetectable		 2fcnA-4jwcA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 4jwc CHAPERONE PROTEIN
DNAK
(Escherichia
coli) 		3 / 3 LYS A 548
GLY A 468
PRO A 470
 None
 1.00A 2hreB-4jwcA:
undetectable		 2hreB-4jwcA:
23.20