SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY A 223
LEU A 180
TYR A 169
LEU A 170
ALA A 219
 None
 1.42A 1pbcA-4jwgA:
2.7		 1pbcA-4jwgA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.69A 2qmmA-4jwgA:
6.9
2qmmB-4jwgA:
6.8		 2qmmA-4jwgA:
25.32
2qmmB-4jwgA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 11 SER A 187
LEU A 194
LEU A 252
SER A 184
LEU A 183
 None
 1.04A 2xn5A-4jwgA:
undetectable		 2xn5A-4jwgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.72A 3ai9X-4jwgA:
7.5		 3ai9X-4jwgA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 183
ALA A 185
GLY A 203
LEU A 243
VAL A 245
 None
None
ACY  A 302 (-3.9A)
None
None
 0.62A 3gyqB-4jwgA:
9.1		 3gyqB-4jwgA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		3 / 3 MET A 107
GLU A 111
LEU A 115
 None
 0.78A 4v2oB-4jwgA:
undetectable		 4v2oB-4jwgA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 154
GLN A 155
TYR A 162
ASN A 157
 None
 1.03A 4ws0A-4jwgA:
undetectable		 4ws0A-4jwgA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		6 / 12 LEU A 183
ALA A 185
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 None
None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.60A 5nfjB-4jwgA:
24.7		 5nfjB-4jwgA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		6 / 12 LEU A 183
ALA A 185
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 None
None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.61A 5nfjC-4jwgA:
24.7		 5nfjC-4jwgA:
29.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 183
ILE A 202
GLY A 203
LEU A 229
VAL A 248
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.47A 5twjA-4jwgA:
4.9		 5twjA-4jwgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 183
ILE A 202
GLY A 203
LEU A 243
VAL A 248
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.52A 5twjA-4jwgA:
4.9		 5twjA-4jwgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 183
ILE A 202
GLY A 203
LEU A 229
VAL A 248
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.52A 5twjB-4jwgA:
5.4		 5twjB-4jwgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 10 LEU A 183
ILE A 202
GLY A 203
LEU A 243
VAL A 248
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.57A 5twjB-4jwgA:
5.4		 5twjB-4jwgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 183
ILE A 202
GLY A 203
LEU A 229
VAL A 248
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.47A 5twjC-4jwgA:
5.4		 5twjC-4jwgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 183
ILE A 202
GLY A 203
LEU A 243
VAL A 248
 None
ACY  A 302 ( 4.8A)
ACY  A 302 (-3.9A)
None
None
 0.53A 5twjC-4jwgA:
5.4		 5twjC-4jwgA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 6 GLN A 118
VAL A 119
ALA A 137
THR A 138
 None
 1.03A 6cduB-4jwgA:
undetectable
6cduC-4jwgA:
undetectable		 6cduB-4jwgA:
20.62
6cduC-4jwgA:
20.62