SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4jwh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 8 GLU A 267
ARG A  84
LEU A 254
GLU A 257
 None
 0.77A 1cmaA-4jwhA:
undetectable
1cmaB-4jwhA:
undetectable		 1cmaA-4jwhA:
18.58
1cmaB-4jwhA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		3 / 3 SER A 114
ASP A 207
CYH A 215
 None
SAH  A 401 (-3.0A)
SAH  A 401 (-3.3A)
 1.03A 2br4E-4jwhA:
2.5		 2br4E-4jwhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
 0.75A 2qmmA-4jwhA:
7.2
2qmmB-4jwhA:
7.2		 2qmmA-4jwhA:
22.83
2qmmB-4jwhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 8 THR A 120
LEU A  99
ASP A 104
SER A 114
 None
 1.00A 2zw9A-4jwhA:
undetectable		 2zw9A-4jwhA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
 0.74A 3ai9X-4jwhA:
7.7		 3ai9X-4jwhA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU A 183
ALA A 185
GLY A 203
LEU A 243
VAL A 245
 SAH  A 401 (-4.2A)
SAH  A 401 (-3.4A)
SAH  A 401 (-3.1A)
SAH  A 401 (-4.6A)
SAH  A 401 ( 4.8A)
 0.54A 3gyqB-4jwhA:
9.6		 3gyqB-4jwhA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		3 / 3 MET A 107
GLU A 111
LEU A 115
 None
 0.79A 4v2oB-4jwhA:
undetectable		 4v2oB-4jwhA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 265
TRP A 261
ILE A  97
THR A 190
ALA A 227
 None
 1.26A 5ienA-4jwhA:
undetectable		 5ienA-4jwhA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		7 / 12 LEU A 183
ALA A 185
ILE A 202
GLY A 203
ASP A 207
LEU A 229
LEU A 243
 SAH  A 401 (-4.2A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
 0.51A 5nfjB-4jwhA:
25.6		 5nfjB-4jwhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		7 / 12 LEU A 183
ALA A 185
ILE A 202
GLY A 203
ASP A 207
LEU A 229
LEU A 243
 SAH  A 401 (-4.2A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
 0.54A 5nfjC-4jwhA:
25.9		 5nfjC-4jwhA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		5 / 9 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
 SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
 0.67A 5o96A-4jwhA:
8.5
5o96B-4jwhA:
9.2		 5o96A-4jwhA:
20.25
5o96B-4jwhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		6 / 12 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
VAL A 248
 SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-4.8A)
 0.51A 5twjA-4jwhA:
4.7		 5twjA-4jwhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		6 / 10 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
VAL A 248
 SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-4.8A)
 0.54A 5twjB-4jwhA:
6.0		 5twjB-4jwhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		6 / 12 LEU A 183
ILE A 202
GLY A 203
LEU A 229
LEU A 243
VAL A 248
 SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-4.8A)
 0.50A 5twjC-4jwhA:
5.5		 5twjC-4jwhA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 6 GLN A 118
VAL A 119
ALA A 137
THR A 138
 None
 1.03A 6cduB-4jwhA:
undetectable
6cduC-4jwhA:
undetectable		 6cduB-4jwhA:
21.20
6cduC-4jwhA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A 162
CYH A 116
TRP A 159
LEU A 152
 None
 1.35A 6cnjA-4jwhA:
0.0
6cnjB-4jwhA:
undetectable		 6cnjA-4jwhA:
14.61
6cnjB-4jwhA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE
(Schizosaccharomy
ces
pombe) 		4 / 7 TYR A 162
CYH A 116
TRP A 159
LEU A 152
 None
 1.35A 6cnkB-4jwhA:
undetectable
6cnkC-4jwhA:
undetectable		 6cnkB-4jwhA:
14.61
6cnkC-4jwhA:
15.46